ADVANCING NUCLEAR
MEDICINE THROUGH
INNOVATION
Naoko Ishibe, Sc.D.
Nuclear and Radiation Studies Board
The National Academi...
Advancine Nuclear Medicine Through Innovation2
COMMITTEE ON STATE OF
SCIENCE OF NUCLEAR MEDICINE
 Hedvig Hricak, Memorial...
Advancine Nuclear Medicine Through Innovation3
ACKNOWLEDGMENTS
DOE-OBER (Mike Viola)
DOE-NE (John Pantaleo)
NIH (Belind...
Advancine Nuclear Medicine Through Innovation4
BACKGROUND
Basic nuclear medicine research
has been funded through DOE-
OB...
Advancine Nuclear Medicine Through Innovation5
BACKGROUND
 Funding for the Program was cut by
85% ($23M) in FY’06
SOURCE:...
Advancine Nuclear Medicine Through Innovation6
Impact of Cut to DOE
Program
In FY2005, 32 principal
investigators, 18 tec...
Advancine Nuclear Medicine Through Innovation7
Impact of Cut to DOE Program
 Research that was terminated include:
 Deve...
Advancine Nuclear Medicine Through Innovation8
STATEMENT OF TASK
The National Academies will perform a “state
of the scien...
Advancine Nuclear Medicine Through Innovation9
STATEMENT OF TASK
3. national impediments to the efficient entry
of promisi...
Advancine Nuclear Medicine Through Innovation10
STATEMENT OF TASK
In light of these future needs, the National
Academies s...
Advancine Nuclear Medicine Through Innovation11
EMERGING
OPPORTUNITIES
Assessing the efficacy of new
drugs
Developing ta...
FINDINGS
AND
RECOMMENDATIONS
Advancine Nuclear Medicine Through Innovation13
Loss of Federal Commitment
for Nuclear Medicine Research
A national nucle...
Advancine Nuclear Medicine Through Innovation14
Cumbersome Regulatory
Requirement
Clarify and simplify
regulatory require...
Advancine Nuclear Medicine Through Innovation15
Inadequate Domestic Supply of
Medical Radionuclides for
Research
Consider...
Advancine Nuclear Medicine Through Innovation16
Shortage of Trained Nuclear
Medicine Scientists
NIH and DOE, in conjuncti...
Advancine Nuclear Medicine Through Innovation17
Need for Technology
Development and Transfer
DOE-OBER should continue to
...
Advancine Nuclear Medicine Through Innovation18
BRIEFINGS
 DOE-OBER
 DOE-Nuclear Energy
 NIH-Office of the Director
 N...
Advancine Nuclear Medicine Through Innovation19
Progress Since Report Release
Senate Energy and Water
Development Appropr...
Advancine Nuclear Medicine Through Innovation20
Progress Since Report Release
Advancine Nuclear Medicine Through Innovation21
Progress Since Report
Release
 Op-Ed in Des Moines Register
 Interested ...
Advancine Nuclear Medicine Through Innovation22
http://www.nap.edu/catalog/11985.h
of 22

Naoko Ishibe

Published on: Mar 3, 2016
Source: www.slideshare.net


Transcripts - Naoko Ishibe

  • 1. ADVANCING NUCLEAR MEDICINE THROUGH INNOVATION Naoko Ishibe, Sc.D. Nuclear and Radiation Studies Board The National Academies November 29, 2007 Presentation to the Biological and Environmental Research Advisory Committee Meeting
  • 2. Advancine Nuclear Medicine Through Innovation2 COMMITTEE ON STATE OF SCIENCE OF NUCLEAR MEDICINE  Hedvig Hricak, Memorial Sloan Kettering Cancer Center (CHAIR)  Jim Adelstein, Harvard Medical School  Peter Conti, University of Southern California  Joanna Fowler, Brookhaven National Laboratory  Joe Gray, Lawrence Berkeley National Laboratory  Lin-wen Hu, Massachusetts Institute of Technology  Joel Karp, University of Pennsylvania  Tom Lewellen, University of Washington  Roger Macklis, Cleveland Clinic  Doug Maynard, Wake Forest University School of Medicine  Tom Ruth, Tri-University Meson Facility  Heinrich Schelbert, UCLA  Gustav von Schulthess, University Hospital of Zurich  Michael Zalutsky, Duke University
  • 3. Advancine Nuclear Medicine Through Innovation3 ACKNOWLEDGMENTS DOE-OBER (Mike Viola) DOE-NE (John Pantaleo) NIH (Belinda Seto)
  • 4. Advancine Nuclear Medicine Through Innovation4 BACKGROUND Basic nuclear medicine research has been funded through DOE- OBER’s Medical Applications and Measurement Sciences Program.
  • 5. Advancine Nuclear Medicine Through Innovation5 BACKGROUND  Funding for the Program was cut by 85% ($23M) in FY’06 SOURCE: DOE-OBER Nuclear Medicine (NM) Budget Profile 31.9 28.8 30.2 30.7 5.4 5.3 23.6 22.8 24.4 3.5 3.4 8.3 6.0 4.8 6.3 1.9 25.4 1.9 0 5 10 15 20 25 30 35 2002 2003 2004 2005 2006 2007 Years $Millions NM Total Radiopharmaceuticals Instrumentation
  • 6. Advancine Nuclear Medicine Through Innovation6 Impact of Cut to DOE Program In FY2005, 32 principal investigators, 18 technicians and 19 post-doctoral and graduate students were supported by the DOE-OBER program. Subsequently, 13 staff and 9 students left due to the cut in funding (33% loss).
  • 7. Advancine Nuclear Medicine Through Innovation7 Impact of Cut to DOE Program  Research that was terminated include:  Development of the helium-3 based accelerator as a table-top generator of 15 MeV protons  Clinical testing of new prostate PET camera  Development of new technetium chemistry in its application in biological systems
  • 8. Advancine Nuclear Medicine Through Innovation8 STATEMENT OF TASK The National Academies will perform a “state of the science” review of nuclear medicine and will provide findings and recommendations on the following issues: 1. future needs for radiopharmaceutical development for the diagnosis and treatment of human disease. 2. future needs for computational and instrument development for more precise localization of radiotracers in normal and aberrant cell physiologies.
  • 9. Advancine Nuclear Medicine Through Innovation9 STATEMENT OF TASK 3. national impediments to the efficient entry of promising new radiopharmaceutical compounds into clinical feasibility studies and strategies to overcome them. 4. impacts of shortages of isotopes and highly trained radiopharmaceutical chemists and other nuclear medicine scientists on nuclear medicine basic and translational research, drug discovery, and patient care, and short- and long-term strategies to alleviate these shortages if they exist.
  • 10. Advancine Nuclear Medicine Through Innovation10 STATEMENT OF TASK In light of these future needs, the National Academies should examine the Medical Applications and Measurement Sciences Program and make recommendations to improve its research and isotope impacts on nuclear medicine. These recommendations should address both research thrusts and facility capabilities but should not address program management issues.
  • 11. Advancine Nuclear Medicine Through Innovation11 EMERGING OPPORTUNITIES Assessing the efficacy of new drugs Developing targeted radionuclide therapeutics Developing hybrid imaging instruments
  • 12. FINDINGS AND RECOMMENDATIONS
  • 13. Advancine Nuclear Medicine Through Innovation13 Loss of Federal Commitment for Nuclear Medicine Research A national nuclear medicine research program should be coordinated between DOE and NIH, with the former emphasizing the general development of technology and the latter the disease-specific applications.
  • 14. Advancine Nuclear Medicine Through Innovation14 Cumbersome Regulatory Requirement Clarify and simplify regulatory requirements, including those for toxicology and current good manufacturing practices. Imaging protocols need to be standardized.
  • 15. Advancine Nuclear Medicine Through Innovation15 Inadequate Domestic Supply of Medical Radionuclides for Research Consider building a dedicated accelerator and upgrading existing research nuclear reactor.
  • 16. Advancine Nuclear Medicine Through Innovation16 Shortage of Trained Nuclear Medicine Scientists NIH and DOE, in conjunction with professional societies, should consider convening expert panels to identify the most critical national needs and determine how to develop appropriate curricula to train the next generation of nuclear medicine scientists.
  • 17. Advancine Nuclear Medicine Through Innovation17 Need for Technology Development and Transfer DOE-OBER should continue to encourage interdisciplinary collaborations between chemists, physicists, engineers, and computer scientists that can be effectively translated into the clinic.
  • 18. Advancine Nuclear Medicine Through Innovation18 BRIEFINGS  DOE-OBER  DOE-Nuclear Energy  NIH-Office of the Director  NCI  NIBIB  OMB  OSTP  Congressional staff
  • 19. Advancine Nuclear Medicine Through Innovation19 Progress Since Report Release Senate Energy and Water Development Appropriations included $34M for the Medical Applications and Measurement Sciences Program, with $20M dedicated to nuclear medicine research. House version did not include funding for nuclear medicine research.
  • 20. Advancine Nuclear Medicine Through Innovation20 Progress Since Report Release
  • 21. Advancine Nuclear Medicine Through Innovation21 Progress Since Report Release  Op-Ed in Des Moines Register  Interested researchers have contacted their Senators and Representatives  Request by Chemical Sciences Roundtable for Presentation at next meeting (February 2008)
  • 22. Advancine Nuclear Medicine Through Innovation22 http://www.nap.edu/catalog/11985.h

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