Preventing blindness with damaged cells studies; and how the location and histone code influence in Epigenomics. Molecular biology folding.
By Camilo Arias Rodríguez. Medical student. UPB.
Published on: Mar 4, 2016
Transcripts - Preventing blindness with damaged cells studies; and how the location and histone code influence in Epigenomics. Molecular biology folding.
Preventing blindness with damaged cells studies; and how the location and histone code influence in Epigenomics.Camilo Arias RodríguezMedical student.
IntroductionEpigenetics: Non genetic factorsinfluencing DNA structure.Eye as a focus of degenerativediseases, leading to blindness.Research as a way to understand,solve and improve.
Mohammad Haeri, Barry E. Knox,Aphrodite Ahmadi.Modeling theFlexural Rigidity of RodPhotoreceptors.Biophysical Journal,2013; 104 (2): 300 DOI:
Average photoreceptor:-Cilyndrical shape.- Outer segment.- Discs.- Function: To convert light intochemical and electric signals.
Closer eye cell structure.Discs of the outer segmentare vulnerable to damageand breakage (mutations).Because of rhodopsin highconcentration.
High density bands High rhodopsin concentration Vulnerable to damage andLow density bands breakage.Average rhodopsin Degenerative diseases Flexible andconcentration can lead easily to steady. blindness.
Student commentI think the mutation in the photoreceptors discs, can be used as adiagnosis help, to define how many risks does a patient have to turn blind.
Menzies Chen, Katherine Licon, ReiOtsuka, Lorraine Pillus, TreyIdeker. Decoupling Epigenetic andGenetic Effects through SystematicAnalysis of Gene Position.Cell Reports,2013; DOI: 10.1016/j.celrep.2012.12.003
- Histones are the basiccomponent of thechromatin.- Both DNA andhistones, define thelandscape of certaingenes.
Epigenetic AlterationMix of histones Gene identity in genes material expresion.
- It was made a prove which consisted on inserting the gene in differentlocations of chromatine.- Experimental model: Yeast chromosome 1.
Student comment.I consider epigenomics help us to discover how can the environment affect somegenes expression, and how can they produce amutation, giving us tools to prevent those diseases
Medical utilityStudent comment. New theory We’ll be able to understand easier the causes of retinal and eye diseases in general, and their development.
Medical utilityStudent comment. New theory New treatments and cures based on the theory of the high concentration of rhodopsin in discs, will treat in a better way patients with eye diseases, evoiding getting blind.
Medical utilityStudent comment. New theory Tools to make more researches about genes.
Medical utilityStudent comment. New theory Will help us understanding how genes work, and to make a relation between their location and themselves, and how can diseases appear and work depending on their chromatin ‘environment’.
•· [Http://sciencedaily.com/releases/2013/01/130103130756.htm] Checkedon January 29th of 2013, 22:50. “In Epigenomics, Location Is Everything:Researchers Exploit Gene Position to test: ‘Histone Code’”•· [http://sciencedaily.com/releases/2013/01/130122122403.htm] Checked onJanuary 29th of 2013, 22:32. “Study of How Eye Cells Become Damaged CouldHelp Prevent Blindness:”
“Be determined, hug life andlive with passion.Lose with class and win withcourage.The World belongs to those whoface no fear and life is toovaluable to feel insignificant.”