 In ancient time, Indian Ayurvedic system of
medicine used nasal route for administration
of drug, called “Nasya”.
 It h...
 Parenteral route is also an inconvenient route for
long term therapy due to the potential side
effects.
 Psychotropic s...
 Avoids hepatic first pass metabolism, gut wall
metabolism.
 Non- invasive route of administration.
 Convenient and eas...
 Nasal pathology
 Absorption enhancers used in nasal drug delivery system
may cause toxicity
 Nasal cavity provides sma...
A - superior turbinate
B - middle turbinate
C - inferior turbinate
D - vestibule
E - nasopharynx
Dotted areas - the olfact...
 Nasal passage, which runs from the nasal
vestibule, to the nasopharynx
 Nasopharynx depth 12-14cms
 Lining is ciliated...
1. Nasal vestibule and Ostium
2. Nasal turbinates
3. Mucus and cilia
4. Olfactory region
 The rate of diffusion and rate of clearance from the
nasal cavity is influenced by:
1. The physicochemical properties of...
1. Effect of molecular size:
Nasal absorption decreases for drugs with molecular
weight > 1000 dalton.
2. Effect of perfus...
3. Effect of solution pH:
The effect of the pH of a perfusion solution on nasal
absorption was examined using a water solu...
 This was investigated using SS-6, an octapeptide
and horseradish peroxidase, a protein molecule.
 Two mechanisms of tra...
 Aqueous route of transport
 This route is slow and passive
 There is an inverse correlation between intranasal
absorpt...
 Transport through a lipoidal route
 Responsible for the transport of lipophilic drugs
that show a rate dependency on th...
 Enhancement in Absorption:
To modify the physicochemical properties of a drug.
 Salt or ester formation:
Has better tra...
1. Metered dose nebulizer
2. Mucoadhesive powder sprays
3. Sustained release formulations
4. Nasal sprays
5. Nasal drops
6...
 Operates by mechanical actuation.
 Delivers a predetermined volume with precision
Eg: Corticosteroids, Tramazoline and ...
 Used for the delivery of insulin
 Produces a drug absorption that is more
effective and less irritating than liquid for...
 For the mucoadhesive powder spray,
The powder mixture was prepared with HPC and
was administered by a special applicator...
 They do not give reproducible dosing.
 They deposit at their impaction site, in the
anterior, unciliated regions of the...
 Rely upon the instillation of one or more drops
of drug solution into the nasal cavity.
 Nasal drops if administered co...
1) In vivo nasal absorption model
2) Ex vivo nasal perfusion model.
1) In-vivo nasal absorption model:
Animal models used ...
 An incision is made in the neck and the trachea is
cannulated.
 Another tube is inserted through the esophagus
towards ...
 A funnel is provided underneath the nose to lead
the drug solution into the drug reservoir.
 Reservoir solution is circ...
 Novel drug delivery system- By Yie.W.Chein,
Page no-229-265.
 Targeted and controlled drug delivery systems-
By S.P.Vya...
Naqeeba nasal drug delivery system
Naqeeba nasal drug delivery system
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Naqeeba nasal drug delivery system

MPharm pharmaceutics ppt nasal drug deliery system
Published on: Mar 3, 2016
Published in: Health & Medicine      
Source: www.slideshare.net


Transcripts - Naqeeba nasal drug delivery system

  • 1.  In ancient time, Indian Ayurvedic system of medicine used nasal route for administration of drug, called “Nasya”.  It has been an accepted form of treatment in Ayurvedic system of Indian medicine.  Certain drugs are unsuitable for oral administration.
  • 2.  Parenteral route is also an inconvenient route for long term therapy due to the potential side effects.  Psychotropic substances and hallucinogens have been used in the form of snuffs.  Many drugs have better BA by the nasal route than by oral route.  This is attributed to a rich vasculature and a highly permeable structure of the nasal mucosa.
  • 3.  Avoids hepatic first pass metabolism, gut wall metabolism.  Non- invasive route of administration.  Convenient and easily accessible.  Absorption will be faster producing rapid effect and better BA.  Drugs with poor oral bioavailability are suitable candidates.
  • 4.  Nasal pathology  Absorption enhancers used in nasal drug delivery system may cause toxicity  Nasal cavity provides smaller absorption surface area when compared to GIT  Immunological reaction  Rapid mucociliary clearance
  • 5. A - superior turbinate B - middle turbinate C - inferior turbinate D - vestibule E - nasopharynx Dotted areas - the olfactory region
  • 6.  Nasal passage, which runs from the nasal vestibule, to the nasopharynx  Nasopharynx depth 12-14cms  Lining is ciliated, highly vascular, rich in mucous glands and goblet cells  Cilium-5μm in length & 0.2 μm in diameter and moves @20beats/sec  Normal pH in the range of 5.5- 6.5 and contain a variety of enzymes.
  • 7. 1. Nasal vestibule and Ostium 2. Nasal turbinates 3. Mucus and cilia 4. Olfactory region
  • 8.  The rate of diffusion and rate of clearance from the nasal cavity is influenced by: 1. The physicochemical properties of the formulation vehicle. 2. The particle size. 3. Surface charge of a drug. 4. Any additives incorporated.
  • 9. 1. Effect of molecular size: Nasal absorption decreases for drugs with molecular weight > 1000 dalton. 2. Effect of perfusion rate: Eg: Phenobarbitol As the perfusion rate increases, nasal absorption first increases and then reaches a plateau level, independent of the rate of perfusion.
  • 10. 3. Effect of solution pH: The effect of the pH of a perfusion solution on nasal absorption was examined using a water soluble ionisable compound such as benzoic acid in the pH range 2 - 7.1 4. Effect of drug concentration: Eg: Monitoring the disappearance of 1-tyrosyl 1- tyrosine and the formation of 1-tyrosine. The nasal absorption of 1-tyrosine depends upon its concentration.
  • 11.  This was investigated using SS-6, an octapeptide and horseradish peroxidase, a protein molecule.  Two mechanisms of transport are involved: 1. Transcellular – Across the cell 2. Paracellular – Between the cell
  • 12.  Aqueous route of transport  This route is slow and passive  There is an inverse correlation between intranasal absorption and the molecular weight of water-soluble compounds  Good systemic BA can be achieved for molecules with a molecular wt of up to 1000 daltons with enhancer
  • 13.  Transport through a lipoidal route  Responsible for the transport of lipophilic drugs that show a rate dependency on their lipophilicity.  Drug also cross cell membranes by an active transport route via carrier-mediated means or through the opening of tight junctions. Eg: Chitosan
  • 14.  Enhancement in Absorption: To modify the physicochemical properties of a drug.  Salt or ester formation: Has better trans-nasal permeability  Formulation design: Proper selection of formulation excipients could enhance the nasal absorption of drugs.  Surfactants: Incorporation of surfactants could modify the permeability of nasal mucosa.
  • 15. 1. Metered dose nebulizer 2. Mucoadhesive powder sprays 3. Sustained release formulations 4. Nasal sprays 5. Nasal drops 6. The saturated cotton pledget 7. The insufflator
  • 16.  Operates by mechanical actuation.  Delivers a predetermined volume with precision Eg: Corticosteroids, Tramazoline and nasal decongestant.  They have also been explored as the NDDS for the systemically –active drugs
  • 17.  Used for the delivery of insulin  Produces a drug absorption that is more effective and less irritating than liquid forms.  In the nasal cavity, the powder absorbs nasal fluid and becomes swollen
  • 18.  For the mucoadhesive powder spray, The powder mixture was prepared with HPC and was administered by a special applicator called ‘Pulizer’.  The advantages of using HPC: 1) drug dose may be reduced. 2) side effects may be lowered. 3) longer duration of effect is expected.
  • 19.  They do not give reproducible dosing.  They deposit at their impaction site, in the anterior, unciliated regions of the nasal cavity.  Thus leads to slow transport of the moiety along the surface.
  • 20.  Rely upon the instillation of one or more drops of drug solution into the nasal cavity.  Nasal drops if administered correctly, deposit drug throughout the nasal cavity  Clearance of the drops is faster than spray
  • 21. 1) In vivo nasal absorption model 2) Ex vivo nasal perfusion model. 1) In-vivo nasal absorption model: Animal models used are: a)Rat model b)Rabbit model c)Dog model d)Sheep model e)Monkey model.
  • 22.  An incision is made in the neck and the trachea is cannulated.  Another tube is inserted through the esophagus towards the posterior part of the nasal cavity.  Drug solution is delivered to the nasal cavity.  Blood samples are collected from the femoral vein  Gives an idea of the drug absorbed through the nasal mucosa.
  • 23.  A funnel is provided underneath the nose to lead the drug solution into the drug reservoir.  Reservoir solution is circulated through the nasal cavity of the rat.  Perfusion solution passes out from the nostril and flows into the drug reservoir soln again.
  • 24.  Novel drug delivery system- By Yie.W.Chein, Page no-229-265.  Targeted and controlled drug delivery systems- By S.P.Vyas and R.K.Khar, Page no-315-382.  Drug Delivery Systems by Kewal K. Jain, Pg 9-10.

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