1
PROTEIN BASED NANO
MACHINES FOR SPACE
APPLICATIONS
Dr. Constantinos Mavroidis, Associate Professor
Department of Me...
2
THE TEAM
Dr. C. Mavroidis
Associate Professor
Mechanical Engineering,
Rutgers University
Dr. M. Yarmush
Chair, Bi...
OUR VISION
To Develop Protein Based NanoMachines and Robots
Novel
Biological
Multi-Degree of Freedom
Apply Forces
Ma...
4
APPLICATIONS
Outer Space and Planetary Missions
Colonization
Workstations
Manufacturing
Military
Medical
5
APPLICATIONS
Bio-Nano-Robot Repairing a Damaged Blood Cell
6
0-10 YEARS: DEVELOPMENT
OF BIO NANO COMPONENTS
DNA VPL Motor Bacteriorhodopsin
DNA – Structural Member, Power Source...
7
MACRO-NANO EQUIVALENCE
Structural Elements
Metal, Plastic Polymer DNA, Nanotubes
Power Sources
Electric Motors,
Pn...
8
MACRO-NANO EQUIVALENCE
Compliance Devices
Springs
Various Types of Gears,
Belts, Chains etc.
β-Sheets
VPL Platfor...
9
MACRO-NANO EQUIVALENCE
Sensors
Light sensors, force sensors,
position sensors, temperature
sensors
Actuated Joints...
10
10-20 YRS: NANOROBOTIC
ASSEMBLIES
ATPase Motor Propelled
Structure – Nanotubes
Legs – Helical Proteins
Vision of ...
20-30 YRS – SELF SUSTAINMENT
AND REPLICATION
11
Self Replication
Sustainment
Swarm Intelligence
Controllability
Space Colonization
Non-living Robots
Bio Mimetic
Remote Sensing
Signal Transmission
12
30-50 YRS – DEPLOYMENT
FOR S...
13
SPECIFIC AIMS FOR PHASE I
Identify Proteins for Use in Nanoscale Mechanisms
Develop Concepts for Bio NanoMachine com...
14
VPL MOTOR CONCEPT
Viral Membrane Peptides
pH Dependent
15
VPL ACTUATED PLATFORMS
Viral Protein Linear Motor Actuated Parallel
Platforms with Controllable Motion
VPL OUTPUT MULTIPLICATION
16
VPL Motors in Parallel –
Force Multiplication
VPL Motors in Series –
Displacement Multip...
17
BIOSENSOR SYSTEM
HSF Protein in Organisms
Responds to Stimuli – Trimerises
Binds to DNA
Color Change
Signal Trans...
18
MULTI- DOF DEVICES
3 VPL Actuators
Nanotubes
DNA Joints
Response to pH Changes
COMPUTATIONAL STUDIES
Model Reversible Folding of VPL Motor Protein
Estimate Forces, Displacements etc. Through Energy
...
20
EXPERIMENTAL WORK
Peptide Selection
Protein Expression
Protein Purification
Protein Conformation as a Function of ...
21
WEBPAGE
http://bionano.rutgers.edu
22
OUTREACH ACTIVITIES
High School Students in Research
Minority Students in Research
Undergraduate Students Employed
Tec...
24
ACKNOWLEDGEMENTS
NASA Institute of Advanced Concepts (NIAC)
SROA Program and Rutgers University, NJ
NSF Nanomanufac...
of 24

Nano machines

Published on: Mar 3, 2016
Source: www.slideshare.net


Transcripts - Nano machines

  • 1. 1 PROTEIN BASED NANO MACHINES FOR SPACE APPLICATIONS Dr. Constantinos Mavroidis, Associate Professor Department of Mechanical and Aerospace Engineering Rutgers, The State University of New Jersey NIAC Phase I Grant
  • 2. 2 THE TEAM Dr. C. Mavroidis Associate Professor Mechanical Engineering, Rutgers University Dr. M. Yarmush Chair, Biomedical Engineering, Rutgers University Dr. M. S. Tomassone Assistant Professor, Biochemical Engineering Rutgers University Dr. F. Papadimitrakopoulos Associate Professor Department of Chemistry University of Connecticut Dr. B. Yurke Researcher, Bell Laboratories, Lucent Technologies Inc. Mr. Atul Dubey Graduate Student Rutgers University Ms. Angela Thornton Graduate Student Rutgers University Mr. Kevin Nikitczuk Undergraduate Student Rutgers University
  • 3. OUR VISION To Develop Protein Based NanoMachines and Robots Novel Biological Multi-Degree of Freedom Apply Forces Manipulate Objects Move From Nano to Macro Lightweight / Efficient Self-Assembling Self-Reproducing 3
  • 4. 4 APPLICATIONS Outer Space and Planetary Missions Colonization Workstations Manufacturing Military Medical
  • 5. 5 APPLICATIONS Bio-Nano-Robot Repairing a Damaged Blood Cell
  • 6. 6 0-10 YEARS: DEVELOPMENT OF BIO NANO COMPONENTS DNA VPL Motor Bacteriorhodopsin DNA – Structural Member, Power Source VPL – Protein Based Actuator Bacteriorhodopsin, HSF – Nano Sensors
  • 7. 7 MACRO-NANO EQUIVALENCE Structural Elements Metal, Plastic Polymer DNA, Nanotubes Power Sources Electric Motors, Pneumatic Actuators, Smart Materials, Batteries, etc. ATPase, VPL Motor, DNA
  • 8. 8 MACRO-NANO EQUIVALENCE Compliance Devices Springs Various Types of Gears, Belts, Chains etc. β-Sheets VPL Platforms, DNA Double Crossover Molecules Transmission Elements
  • 9. 9 MACRO-NANO EQUIVALENCE Sensors Light sensors, force sensors, position sensors, temperature sensors Actuated Joints Revolute, Prismatic, Spherical Joints etc. Rhodopsin, Heat Shock Factor DNA Nanodevices, Nanojoints
  • 10. 10 10-20 YRS: NANOROBOTIC ASSEMBLIES ATPase Motor Propelled Structure – Nanotubes Legs – Helical Proteins Vision of a Nano Robot
  • 11. 20-30 YRS – SELF SUSTAINMENT AND REPLICATION 11 Self Replication Sustainment Swarm Intelligence Controllability
  • 12. Space Colonization Non-living Robots Bio Mimetic Remote Sensing Signal Transmission 12 30-50 YRS – DEPLOYMENT FOR SPACE COLONIZATION Courtesy: http://members.cox.net/kableguy/bryceworks/
  • 13. 13 SPECIFIC AIMS FOR PHASE I Identify Proteins for Use in Nanoscale Mechanisms Develop Concepts for Bio NanoMachine components Develop Dynamic Models and Realistic Simulations Perform a Series of Biomolecular Experiments Assembly and Interface NanoMachine Components
  • 14. 14 VPL MOTOR CONCEPT Viral Membrane Peptides pH Dependent
  • 15. 15 VPL ACTUATED PLATFORMS Viral Protein Linear Motor Actuated Parallel Platforms with Controllable Motion
  • 16. VPL OUTPUT MULTIPLICATION 16 VPL Motors in Parallel – Force Multiplication VPL Motors in Series – Displacement Multiplication
  • 17. 17 BIOSENSOR SYSTEM HSF Protein in Organisms Responds to Stimuli – Trimerises Binds to DNA Color Change Signal Transmission
  • 18. 18 MULTI- DOF DEVICES 3 VPL Actuators Nanotubes DNA Joints Response to pH Changes
  • 19. COMPUTATIONAL STUDIES Model Reversible Folding of VPL Motor Protein Estimate Forces, Displacements etc. Through Energy Software Usage - CHARMM Input – Structure Files in .pdb Format Output – Simulated Energy and Displacements Microsecond Modeling – Assumptions, Targeted MD Parallel Processing Facilities at CAIP (Teal) Comparison with Experimental Observations 19
  • 20. 20 EXPERIMENTAL WORK Peptide Selection Protein Expression Protein Purification Protein Conformation as a Function of pH Calculate Force Expended upon Extension Reversibility Different Sequence - Different Designs
  • 21. 21 WEBPAGE http://bionano.rutgers.edu
  • 22. 22
  • 23. OUTREACH ACTIVITIES High School Students in Research Minority Students in Research Undergraduate Students Employed Technology Transfer International and Industry Collaboration Colloquiums, Symposia and Journal Clubs Interdepartmental Course on Bio Nano Technology 23
  • 24. 24 ACKNOWLEDGEMENTS NASA Institute of Advanced Concepts (NIAC) SROA Program and Rutgers University, NJ NSF Nanomanufacturing Program

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