An emulsion is usually comprised of two or more
immiscible liquids where one liquid in the form of
droplets is dispersed (...
 Propofol (2,6-diisopropylphenol) is a
potent lipophilic anesthetic that is an oil-in-
water or lipid-based emulsion.
Injectable Propofol emulsion is Nano
Emulsion
99% particles are in nano meter size
range (1 nano meter-500 nano meter).
So...
The minimum diameter of human
blood capillary is 5-7 micron.
If the injectable emulsion has fat
globules/particles larger ...
Histology: Oil-Red-O staining of fat
Stable Infusion Unstable Infusion
DFD-HMS-06
 Method I – Dynamic or Static Light Scattering
 Mean Droplet Size (MDS), expressed as the
intensity-weighted MDS, and mu...
Lipid Emulsion Profiles:Lipid Emulsion Profiles:
Soybean Oil-Based ProductsSoybean Oil-Based Products
ProductProduct Lot N...
Why Techno Drugs Propofol is UniqueWhy Techno Drugs Propofol is Unique
 Study report shows Techno Drugs Propofol emulsion...
Thank
You
Nano emulsion propofol (Techno Drugs Ltd)
Nano emulsion propofol (Techno Drugs Ltd)
Nano emulsion propofol (Techno Drugs Ltd)
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Nano emulsion propofol (Techno Drugs Ltd)

Techno Drugs Ltd 31, Segun Bagicha Dhaka 1000
Published on: Mar 3, 2016
Published in: Health & Medicine      
Source: www.slideshare.net


Transcripts - Nano emulsion propofol (Techno Drugs Ltd)

  • 1. An emulsion is usually comprised of two or more immiscible liquids where one liquid in the form of droplets is dispersed (the dispersed phase) in another liquid (the continuous phase) The surface of each droplet is an interface between hydrophilic and hydrophobic molecules Emulsion is thermodynamically unstable  The stability of an emulsion can also be affected by many external factors including storage methods (glass vs. plastic), time, and temperature.
  • 2.  Propofol (2,6-diisopropylphenol) is a potent lipophilic anesthetic that is an oil-in- water or lipid-based emulsion.
  • 3. Injectable Propofol emulsion is Nano Emulsion 99% particles are in nano meter size range (1 nano meter-500 nano meter). Some Particles are micron range Those bigger particles are produced due to high pressure homogenization inefficiency, emulsion instability or various other factors According to the USP 729, particles bigger than 5 micron should be less than 0.05% So the boundary is size >5 micron amount <0.05% which is called PFAT5.  Conventional Emulsion: 1-20 µm Nano/Micro Emulsion: 10-200 nm
  • 4. The minimum diameter of human blood capillary is 5-7 micron. If the injectable emulsion has fat globules/particles larger than 5 micron it will block the blood capillary. The normal blood flow will be stopped. Thus blood vessel embolism may cause death to a patient.
  • 5. Histology: Oil-Red-O staining of fat Stable Infusion Unstable Infusion DFD-HMS-06
  • 6.  Method I – Dynamic or Static Light Scattering  Mean Droplet Size (MDS), expressed as the intensity-weighted MDS, and must be < 500 nm  Method II – Light Extinction employing Single- Particle Optical Sensing  Large-Diameter Tail, expressed as the volume- weighted percentage of fat > 5 micrometers or PFAT > 5 µm or PFAT5 , and must be < 0.05%
  • 7. Lipid Emulsion Profiles:Lipid Emulsion Profiles: Soybean Oil-Based ProductsSoybean Oil-Based Products ProductProduct Lot No.Lot No. MDS (nm) PFAT5 Intralipid 10%Intralipid 10% 12202-5112202-51 286286 0.009%0.009% Intralipid 20%Intralipid 20% 10776-7110776-71 340340 0.009%0.009% Intralipid 30%Intralipid 30% 16115-5116115-51 420420 0.007%0.007% Liposyn III 10%Liposyn III 10% 45351-DE45351-DE 263263 0.013%0.013% Liposyn III 20%Liposyn III 20% 43440-DE43440-DE 307307 0.005%0.005% Liposyn III 30%Liposyn III 30% 41395-DE41395-DE 301301 0.029%0.029% Lipofundin N 10%Lipofundin N 10% 8085A838085A83 272272 0.001%0.001% Lipofundin N 20%Lipofundin N 20% 8082A848082A84 332332 0.005%0.005% Techno DrugsTechno Drugs Propofol EmulsionPropofol Emulsion XXXXXXXXXXXX 220220 N/AN/A Boldface = Lipids currently available in the U.S.;= Lipids currently available in the U.S.; USP Globule Size Limits: MDS < 500 nm; PFAT5 < 0.05%MDS < 500 nm; PFAT5 < 0.05%
  • 8. Why Techno Drugs Propofol is UniqueWhy Techno Drugs Propofol is Unique  Study report shows Techno Drugs Propofol emulsion contain Smallest Mean Droplet Size (220 nm) of emulsion Fat Globule Comparing to world famous Injectable Emulsion  Since, 220 nm globule size is much smaller than human smallest capillary (5-7 micron) therefore, there is no risk for capillary blockage and embolism  In Bangladesh market, Techno Drugs is the only company who is using Injectable emulsion globule size analyzer from “Particle Sizing System, USA”. The instrument is USP 729 compliance.  For efficient homogenization of Propofol emulsion Techno Drugs using world famous High Pressure Homogenizer from Avestin, Canada.  To ensure patient safety and quality of propofol emulsion Techno Drugs using all the equipment from Europe and USA.
  • 9. Thank You

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