Nanoparticle Based Liposome Drug Delivery
Nilima Kanwar Hada*, Mahendra Singh ...
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Nanoparticle based liposome drugs delivery

Published on: Mar 3, 2016
Published in: Technology      

Transcripts - Nanoparticle based liposome drugs delivery

  • 1. Nanoparticle Based Liposome Drug Delivery NANO PARTICLE BASED LIPOSOME DRUG DELIVERY Nilima Kanwar Hada*, Mahendra Singh Ashawat, Aniruddh Singh --------------------------------------------------------------------------------------------------------------------------- Artificial membranes under appropriate conditions form small and closed vesicles called liposome, composed of a lipid bilayer that encloses a small droplet of water in a range of sizes from about 20 nm to 10 m. Liposome are nontoxic, nonimmunogenic, and biodegradable and increases the lifetime of drugs that are rapidly cleared from the blood. They are particularly useful for delivering drugs those are very potent and toxic and for targeting drugs to given locations e.g. for delivering drugs to macrophages in the blood. These immuneliposomes are cleared from the blood by macrophages, which engulf and digest them, releasing the drugs directly inside the cell in the process. This is perfect treatment of Leishmania infection. Leishmania is an organism that infects macrophages and lives inside the cells because they are inside the cells, the immune system cannot control the infection, but drugs in immunoliposomes can attack the problem at its location. Liposome can also decrease the neurotoxicity of drugs. Many drugs pass out of the bloodstream into the brain. If a drug is stored in a large liposome, it is blocked by the blood-brain barrier (BBB), reducing possible side effects on nervous tissue. Liposome effectively penetrates the skin, delivering molecules to cells in the lower layers. This property of liposome has been used to great advantage in the cosmetics industry, where liposome are added to skin creams and other products applied to the body surface. Liposome may be designed to deliver specific lipids to the skin by including the lipids in the bilayer. These are based on the ability of liposome to solubilise hydrophobic molecules in natural lipid-water systems, act as slow release capsules and enhance penetration through mucosal membranes. Vitamins, tanning agents, sunscreens, minerals and herb extracts for oral administration are also commonly enclosed within liposome for delivery. A liposomal vaccine against hepatitis A has been successfully launched by the Swiss Serum Institute. Doxil (Sequus) is a formulation of doxorubicin precipitated in sterically stabilized liposome while DaunoXome (NeXstar) is daunorubicin encapsulated in small liposomes with very strong and cohesive bilayers, which can be referred to as mechanical stabilization. Because naked lipid vesicles are not normally found in the blood, liposomes are rapidly removed from the bloodstream. To increase their effective lifetime in circulation, research professionals have developed stealth liposome that evades the natural clearance mechanisms. One approach is to coat the liposome with large, neutral polymers. These form a barrier that interacts only weakly with the natural molecules in the blood, such as the antibodies and blood-clotting proteins that normally interact with foreign bodies. Thus liposome may circulate for several days in the bloodstream, acting as a time-release reservoir of drug molecules. ----------------------------------------------------------------------------------------------------------------------* Institute of Clinical Research India, Mumbai Hada N.K., Ashawat M.S., Singh Aniruddh Page 1

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