Quantum Spin-Off project is funded by the European Commission. This communication reflects the views of the author,
and th...
12 May 2015 Laimos Junior and Senior High School 2
Structure of the
presentation
1st Part: the product- magnetic
nanoparti...
12 May 2015 Laimos Junior and Senior High School 6
1st Part
The product: magnetic
nanoparticles for
applications of magnet...
12 May 2015 Laimos Junior and Senior High School 7
What is nanotechnology?
Nanoscience and nanotechnology are
the study an...
12 May 2015 Laimos Junior and Senior High School 8
Magnetic Hyperthermia
 Magnetic hyperthermia is an experimental cancer...
12 May 2015 Laimos Junior and Senior High School 11
A special case:
Superparamagnetism
•When a ferromagnet or ferrimagnet ...
12 May 2015 Laimos Junior and Senior High School 12
Synthesis of Magnetite
(Fe3O4) Nanoparticles (1)
•In a glass container...
12 May 2015 Laimos Junior and Senior High School 13
Synthesis of Magnetite
(Fe3O4) Nanoparticles- (2)
•The temperature in ...
12 May 2015 Laimos Junior and Senior High School 14
Cleaning the final product (1)
•Initially the product is shared into 1...
12 May 2015 Laimos Junior and Senior High School 15
Cleaning the final product (2)
•The product is transferred to another ...
12 May 2015 Laimos Junior and Senior High School 16
Characterising the final
product (1)
•We use a Leitz Scanning Electron...
12 May 2015 Laimos Junior and Senior High School 17
Characterising the final
product (2)
•The samples are coated with gold...
12 May 2015 Laimos Junior and Senior High School 18
2nd Part
The Business Model Canvas
12 May 2015 Laimos Junior and Senior High School 19
The goal of
Nanomedicine S.A.
Success
12 May 2015 Laimos Junior and Senior High School 20
Business Model Canvas
Success
12 May 2015 Laimos Junior and Senior High School 21
Value Preposition
Our products:
•Thanks to the nanoparticles they cont...
12 May 2015 Laimos Junior and Senior High School 22
Customer Segments
•Private clinics
•Public hospitals
•Doctors- Prescri...
12 May 2015 Laimos Junior and Senior High School 23
Distribution Channels
•Medical salesmen
•Presence in scientific confer...
12 May 2015 Laimos Junior and Senior High School 24
Customer Relations
•We are involved in sponsoring hospital
and clinic ...
12 May 2015 Laimos Junior and Senior High School 25
Key Activities
•Finding suppliers according to their reliability, pric...
12 May 2015 Laimos Junior and Senior High School 26
Key Resources
•Human Resources of various specialties
•Raw materials
•...
12 May 2015 Laimos Junior and Senior High School 27
Key Partners
•Suppliers of raw materials
•Suppliers of packaging mater...
12 May 2015 Laimos Junior and Senior High School 28
Revenue Streams
•Company’s revenue source is its products’
sales
•Cust...
12 May 2015 Laimos Junior and Senior High School 29
Cost Structure
•Purchase/rental of facilities
•Purchase of
electrical...
12 May 2015 Laimos Junior and Senior High School 30
3rd Part
Establishing our company
12 May 2015 Laimos Junior and Senior High School 31
The Medical Market in
Greece (1)
•The drug is a social good, so the in...
12 May 2015 Laimos Junior and Senior High School 32
The Medical Market in
Greece (2)
The production and distribution of ph...
12 May 2015 Laimos Junior and Senior High School 33
The establishment of
Nanomedicine S.A.
We created the Spin-Off company...
12 May 2015 Laimos Junior and Senior High School 34
Necessary Formalities
•Issuing of books and documents
•Tax books are c...
12 May 2015 Laimos Junior and Senior High School 35
Nanomedicine’s Chart
CEO
Ioannis Kapouranis
Deputy CEO
Athanassios Tre...
12 May 2015 Laimos Junior and Senior High School 36
Financing the Company
•Equity
•Funded by the Ministry of Development a...
12 May 2015 Laimos Junior and Senior High School 37
Nanomedicine’s Website and
Blog
The website creation is crucial for th...
12 May 2015 Laimos Junior and Senior High School 38
Nanomedicine’s objective
and vision
“Possessing flexibility, speed and...
12 May 2015 Laimos Junior and Senior High School 39
Useful References
Bakandritsos, G. Mattheolabakis, G. Chatzikyriakos,...
12 May 2015 Laimos Junior and Senior High School 40
End of presentation
Thank you for your attention!!!
 Read more in our...
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Nanomedicine S.A. Laimos High School

Final Presentation of our team in the European Final Contest Quantum Spin-Off
Published on: Mar 3, 2016
Published in: Education      
Source: www.slideshare.net


Transcripts - Nanomedicine S.A. Laimos High School

  • 1. Quantum Spin-Off project is funded by the European Commission. This communication reflects the views of the author, and the Commission cannot be held responsible for any use which may be made of the information contained herein. Nanomedicine S. A. Laimos Junior and Senior High School Academic year 2014-2015 Participation in the European Nanotechnology Contest for High School students “Quantum Spin-Off” An action belonging to the European Program “Inspiring Science Education.” (I.S.E.) Presenters: Anastassiadou Andriana Charissi Zoi Delkou Kiriaki Kazoglou Antigoni Kazoglou Evangellia Nalpantidou Christina Sampsonidou- MichaiIidou Georgia Sampsonidou- Michailidou Penelope Sotiri Dimitrios Paraskevopoulou Aristea Tsili Antonia
  • 2. 12 May 2015 Laimos Junior and Senior High School 2 Structure of the presentation 1st Part: the product- magnetic nanoparticles for applications of magnetic hyperthermia. 2nd Part : the establishment and the characteristics of the Spin- Off company. 3rd Part: the medicine market in Greece.
  • 3. 12 May 2015 Laimos Junior and Senior High School 6 1st Part The product: magnetic nanoparticles for applications of magnetic hyperthermia
  • 4. 12 May 2015 Laimos Junior and Senior High School 7 What is nanotechnology? Nanoscience and nanotechnology are the study and the application of extremely small things that can be used across all the science fields. Science Engineering Technology conducted at the nanoscale (which is about 1 to 100nm, where 1 nm = 1: 1.000.000.000 m).
  • 5. 12 May 2015 Laimos Junior and Senior High School 8 Magnetic Hyperthermia  Magnetic hyperthermia is an experimental cancer treatment which destroys tumors but does not affect the neighboring healthy cells.  Magnetic nanoparticles are put inside a tumor and the whole patient is placed in an alternating magnetic field of well-chosen amplitude and frequency.  The tumor temperature rises until the cancer cells start dying (43 oC).  Our main product is Nanoferrum, a medicine with magnetic nanoparticles, which is applied in the method of magnetic hyperthermia.
  • 6. 12 May 2015 Laimos Junior and Senior High School 11 A special case: Superparamagnetism •When a ferromagnet or ferrimagnet is sufficiently small, it acts like a single magnetic moment. •Its response to an external magnetic field is like a paramagnet, but much stronger. •This is the case of the nanoparticles of magnetite (Fe3O4) and maghemite (γ-Fe2O3, where γ refers to the crystalline structure), which are applied in the method of magnetic hyperthermia.
  • 7. 12 May 2015 Laimos Junior and Senior High School 12 Synthesis of Magnetite (Fe3O4) Nanoparticles (1) •In a glass container with 30 mℓ of water we dissolve under continuous stirring, 150 mg of dextrane, at about 35οC. •In 10 mℓ of water we dissolve 0.0026 moles of dichloride and trichloride ferric in moles portion 2:1, with simultaneous addition of 30μℓ of concentrated hydrochloric acid(HCl 37%).
  • 8. 12 May 2015 Laimos Junior and Senior High School 13 Synthesis of Magnetite (Fe3O4) Nanoparticles- (2) •The temperature in the container rises up to 40οC, so 2 mℓ of ammonium hydroxide (NH4OH, 30%) and the solution of ferric ions are added. •In the first 15 minutes of the reaction the temperature rises further gradually to 55οC and it is stabilized at 60- 70οC for 80 min. •The container is removed from the hob and the product is placed in a water bath to be cooled at 30οC.
  • 9. 12 May 2015 Laimos Junior and Senior High School 14 Cleaning the final product (1) •Initially the product is shared into 10 vials of 2 mℓ and centrifuged (we use a centrifuge device by Bacacos Scientific). •After the centrifugation, the supernatant phase was discarded while the precipitate was collected from the flasks and added to half the amount of water (10 mℓ H2O). •The product is stirred for 15 min (VORTEX).
  • 10. 12 May 2015 Laimos Junior and Senior High School 15 Cleaning the final product (2) •The product is transferred to another container and then it is placed in an ultrasonic bath for 15 min in order to reduce the aggregates generated by centrifugation. •The above process of centrifugation and stirring is repeated. •A mild centrifugation of the colloid for 20 min at 2100g follows for removing larger aggregates by precipitation. •Using a pipette, the bulk of the headspace in the vials is isolated and the colloid is stored in the refrigerator (at 7 ° C) to be examined in the electron microscope.
  • 11. 12 May 2015 Laimos Junior and Senior High School 16 Characterising the final product (1) •We use a Leitz Scanning Electron Microscope (S.E.M.), model Amr 1600T, which belongs to the Ceramic Materials’ Research Laboratory (University of Athens, Department of Physics, Solid State Physics’ Section). •Its function is based on the presence of spatially varying magnetic fields, which act as "magnetic lenses". •The samples are prepared for the S.Ε.Μ. by placing a few droplets of the colloid in appropriate carriers and putting them in an oven at 37οC until they are completely dry.
  • 12. 12 May 2015 Laimos Junior and Senior High School 17 Characterising the final product (2) •The samples are coated with gold under vacuum. •The samples enter the microscope, where we an appropriate 20,00 kV acceleration potential is used. •The samples are enlarged by 2,000 and 5,000 times. In all cases we can see ferric oxide nanoparticles aggregated to each other (thrombosis or flocculation of the colloid emulsion).
  • 13. 12 May 2015 Laimos Junior and Senior High School 18 2nd Part The Business Model Canvas
  • 14. 12 May 2015 Laimos Junior and Senior High School 19 The goal of Nanomedicine S.A. Success
  • 15. 12 May 2015 Laimos Junior and Senior High School 20 Business Model Canvas Success
  • 16. 12 May 2015 Laimos Junior and Senior High School 21 Value Preposition Our products: •Thanks to the nanoparticles they contain, they target only tumors. •They do not afflict the body with side effects •They are made from natural products, which with the help of nanotechnology are homogenized and take the form of injectable solutions. •They promise healing and good quality of life •They are cheaper than the respective ones already marketed.
  • 17. 12 May 2015 Laimos Junior and Senior High School 22 Customer Segments •Private clinics •Public hospitals •Doctors- Prescribers •Pharmacies/pharamceutical depots
  • 18. 12 May 2015 Laimos Junior and Senior High School 23 Distribution Channels •Medical salesmen •Presence in scientific conferences and medicine or pharmacology workshops. •Participation in pharmaceutical fairs •Advertisement of our products via brochures/leaflets etc… •Advertising in medical journals •Creation of a website for online advertising The distribution of products will be accomplished by means of trucks through highways. Our company’s site: users.sch.gr/ivelonak/joomla2015
  • 19. 12 May 2015 Laimos Junior and Senior High School 24 Customer Relations •We are involved in sponsoring hospital and clinic events during festive and commemorative days •We cover doctors’ medical expenses to attend scientific and medical conferences •We offer gifts during festive periods
  • 20. 12 May 2015 Laimos Junior and Senior High School 25 Key Activities •Finding suppliers according to their reliability, pricing policy and their response to the requirements of product and service improvement •Acquisition of machinery •Scientific reserch •Medicine Manufacturing •Advertizing •Sale •Payment of all parties involved (human resources, suppliers, collaborators etc)
  • 21. 12 May 2015 Laimos Junior and Senior High School 26 Key Resources •Human Resources of various specialties •Raw materials •Equipment/machinery •Capital (premises, vechicles) •Cash/Money
  • 22. 12 May 2015 Laimos Junior and Senior High School 27 Key Partners •Suppliers of raw materials •Suppliers of packaging materials •Company’s human resources •Advertisers Everybody’s needs must be met for •Profit •Reputation •Success
  • 23. 12 May 2015 Laimos Junior and Senior High School 28 Revenue Streams •Company’s revenue source is its products’ sales •Customers can pay via bank cheques and e- payments •Nanomedicine S.A. has a stable pricing policy. •Takes into account the volume of transactions •Monitors the fluctuations of the raw materials’ market price and creates its price list accordingly, providing frequent updates to customers.
  • 24. 12 May 2015 Laimos Junior and Senior High School 29 Cost Structure •Purchase/rental of facilities •Purchase of electrical equipment / machinery raw materials  packaging materials cars/vehicles To these, we should add the cost of: •Advertising •Human resources •Product distribution •Lighting •Heating •Water supply •Stationery
  • 25. 12 May 2015 Laimos Junior and Senior High School 30 3rd Part Establishing our company
  • 26. 12 May 2015 Laimos Junior and Senior High School 31 The Medical Market in Greece (1) •The drug is a social good, so the institutional framework defines drastically: the production the distribution the storage the quality assurance the competition the pricing the prescription policy the general market conditions
  • 27. 12 May 2015 Laimos Junior and Senior High School 32 The Medical Market in Greece (2) The production and distribution of pharmaceutical products is one of the most dynamic sectors in Greek industry: increased investments in the sector creation of new units of production that manufacture pharmaceuticals. It is a dynamic industry which makes high profit.
  • 28. 12 May 2015 Laimos Junior and Senior High School 33 The establishment of Nanomedicine S.A. We created the Spin-Off company named Nanomedicine S.A. for manufacturing and selling nanomedicines. It is headquartered in the Industrial Area of Florina. The company is going to be set in a 300 sq.m. building that will be rented for this purpose.
  • 29. 12 May 2015 Laimos Junior and Senior High School 34 Necessary Formalities •Issuing of books and documents •Tax books are confidential and nobody has the right to take knowledge of them, apart from the tax office •Decide on the necessary documents, which are: invoices delivery notes waybills check books block collection receipts.
  • 30. 12 May 2015 Laimos Junior and Senior High School 35 Nanomedicine’s Chart CEO Ioannis Kapouranis Deputy CEO Athanassios Trentos Internal Audit and Information Technology Dimitrios Sotiri Christina Nalpantidou Theodora Lykomani Legal department Aristea Paraskevopoulou Georgia Sampsonidou- Michailidou Department of quality assurance Penelope Sampsonidou- Michailidou Andriana Anastasiadou Research and Development Department Zoi Charissi Elias Papadopoulos Kiriaki Delkou Konstantinos Stavropoulos Public Relations Evangelia Kazoglou Antonia Tsili Marketing Antigoni Kazoglou Fotini Michailidou Sofia Konstantinopoulou Human Resources Manager Raphail Nalpantidis Our company chart includes: CEO and his deputy Human Resources Manager And the following sections: Internal Audit and Information Technology Legal department Department of quality assurance Research and Development Department Public Relations officer Marketing officer
  • 31. 12 May 2015 Laimos Junior and Senior High School 36 Financing the Company •Equity •Funded by the Ministry of Development as a spin-off company upon request •Check the company's possibilities to be funded by the Operational Program named: “Competitiveness , Entrepreneurship and Innovation”.
  • 32. 12 May 2015 Laimos Junior and Senior High School 37 Nanomedicine’s Website and Blog The website creation is crucial for the company’s advertising since suppliers and customers can be informed about our activities. Also, we have created a blog for improving the internal communication of our team.  Our company ‘s site: users.sch.gr/ivelonak/joomla2015  Our blog: http://www.nanophysicslaimos.blogspot.gr
  • 33. 12 May 2015 Laimos Junior and Senior High School 38 Nanomedicine’s objective and vision “Possessing flexibility, speed and adaptation to the new requirements we aim to establish ourselves in a leading pharmaceutical company and offer the community and the Greek economy!! We incorporate new technologies in our work and we rely on our people, who are our strength. Working in Nanomedicine S.A. is aimed to be considered as an important milestone for the realization of their professional ambitions! Together we work with vision, dedication and loyalty to produce quality medicines for the treatment of diseases!”  Read more in our company ‘s site: users.sch.gr/ivelonak/joomla2015
  • 34. 12 May 2015 Laimos Junior and Senior High School 39 Useful References Bakandritsos, G. Mattheolabakis, G. Chatzikyriakos, T. Szabo, V. Tzitzios, D. Kouzoudis, S. Couris, and K. Avgoustakis (2011), Doxorubicin Nanocarriers Based on Magnetic Colloids with a Bio-polyelectrolyte Corona and High Non-linear Optical Response: Synthesis, Characterization, and Properties, Adv. Funct. Mater., 21, 1465–1475 Baron A.R. & Shane S.A. (2008) Entrepreneurship. A process perspective. 2nd edition. South Western. Fred R.D. (2011) Strategic Management. Concepts and cases. 13th edition. Pearson. Goldstein J, Newbury D, Joy D, Lyman C, Echlin P, Lifshin E, Sawyer L and Michael J (2003). Scanning electron microscopy and x-ray microanalysis. Springer. Kotler P., Brady M., Goodman M. & Hansen T. (2009) Marketing Management. Pearson. Sutcliffe, H. (2011). A report on responsible research and innovation. Brussels: Matter. Wanquan Jiang, H.C. Yang, S.Y. Yang, H.E. Horng, J.C. Hung, Y.C. Chen, Chin-Yih Hong (2004), Preparation and properties of superparamagnetic nanoparticles with narrow size distribution and biocompatible, Journal of Magnetism and Magnetic Materials, Volume 283, Issues 2–3, Pages 210-214, ISSN 0304-8853 http://dx.doi.org/10.1016/j.jmmm.2004.05.022.(http://www.sciencedirect.com/s cience/article/pii/S0304885304006304)
  • 35. 12 May 2015 Laimos Junior and Senior High School 40 End of presentation Thank you for your attention!!!  Read more in our blog: http://www.nanophysicslaimos.blogspot.gr