Nanomedicine S.A. Laimos High School
Final Presentation of our team in the European Final Contest Quantum Spin-Off
Published on: Mar 3, 2016
Transcripts - Nanomedicine S.A. Laimos High School
Quantum Spin-Off project is funded by the European Commission. This communication reflects the views of the author,
and the Commission cannot be held responsible for any use which may be made of the information contained herein.
Nanomedicine S. A.
Laimos Junior and Senior High School
Academic year 2014-2015
Participation in the European Nanotechnology Contest for High School
students “Quantum Spin-Off”
An action belonging to the European Program “Inspiring Science
Sampsonidou- MichaiIidou Georgia
Sampsonidou- Michailidou Penelope
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Structure of the
1st Part: the product- magnetic
nanoparticles for applications of
2nd Part : the establishment and
the characteristics of the Spin- Off
3rd Part: the medicine market in
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The product: magnetic
applications of magnetic
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What is nanotechnology?
Nanoscience and nanotechnology are
the study and the application of
extremely small things that can be used
across all the science fields.
conducted at the nanoscale
(which is about 1 to 100nm, where 1 nm
= 1: 1.000.000.000 m).
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Magnetic hyperthermia is an experimental cancer
treatment which destroys tumors but does not affect the
neighboring healthy cells.
Magnetic nanoparticles are put inside a tumor and the
whole patient is placed in an alternating magnetic field
of well-chosen amplitude and frequency.
The tumor temperature rises until the cancer cells start
dying (43 oC).
Our main product is Nanoferrum, a medicine with
magnetic nanoparticles, which is applied in the method
of magnetic hyperthermia.
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A special case:
•When a ferromagnet or ferrimagnet is sufficiently small,
it acts like a single magnetic moment.
•Its response to an external magnetic field is like a
paramagnet, but much stronger.
•This is the case of the nanoparticles of magnetite (Fe3O4)
and maghemite (γ-Fe2O3, where γ refers to the crystalline
structure), which are applied in the method of magnetic
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Synthesis of Magnetite
(Fe3O4) Nanoparticles (1)
•In a glass container with 30 mℓ of water we dissolve
under continuous stirring, 150 mg of dextrane, at about
•In 10 mℓ of water we dissolve 0.0026 moles of
dichloride and trichloride ferric in moles portion 2:1, with
simultaneous addition of 30μℓ of concentrated
hydrochloric acid(HCl 37%).
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Synthesis of Magnetite
(Fe3O4) Nanoparticles- (2)
•The temperature in the container rises up to 40οC, so 2
mℓ of ammonium hydroxide (NH4OH, 30%) and the
solution of ferric ions are added.
•In the first 15 minutes of the reaction the temperature
rises further gradually to 55οC and it is stabilized at 60-
70οC for 80 min.
•The container is removed from the hob and the product
is placed in a water bath to be cooled at 30οC.
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Cleaning the final product (1)
•Initially the product is shared into 10 vials of 2
mℓ and centrifuged (we use a centrifuge device
by Bacacos Scientific).
•After the centrifugation, the supernatant
phase was discarded while the precipitate was
collected from the flasks and added to half the
amount of water (10 mℓ H2O).
•The product is stirred for 15 min (VORTEX).
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Cleaning the final product (2)
•The product is transferred to another container and then it
is placed in an ultrasonic bath for 15 min in order to reduce
the aggregates generated by centrifugation.
•The above process of centrifugation and stirring is
•A mild centrifugation of the colloid for 20 min at 2100g
follows for removing larger aggregates by precipitation.
•Using a pipette, the bulk of the headspace in the vials is
isolated and the colloid is stored in the refrigerator (at 7 °
C) to be examined in the electron microscope.
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Characterising the final
•We use a Leitz Scanning Electron Microscope (S.E.M.),
model Amr 1600T, which belongs to the Ceramic Materials’
Research Laboratory (University of Athens, Department of
Physics, Solid State Physics’ Section).
•Its function is based on the presence of spatially varying
magnetic fields, which act as "magnetic lenses".
•The samples are prepared for the S.Ε.Μ. by placing a few
droplets of the colloid in appropriate carriers and putting
them in an oven at 37οC until they are completely dry.
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Characterising the final
•The samples are coated with gold under vacuum.
•The samples enter the microscope, where we an
appropriate 20,00 kV acceleration potential is used.
•The samples are enlarged by 2,000 and 5,000 times. In
all cases we can see ferric oxide nanoparticles aggregated
to each other (thrombosis or flocculation of the colloid
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The Business Model Canvas
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The goal of
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Business Model Canvas
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•Thanks to the nanoparticles they contain, they
target only tumors.
•They do not afflict the body with side effects
•They are made from natural products, which
with the help of nanotechnology are
homogenized and take the form of injectable
•They promise healing and good quality of life
•They are cheaper than the respective ones
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•Presence in scientific conferences and
medicine or pharmacology workshops.
•Participation in pharmaceutical fairs
•Advertisement of our products via
•Advertising in medical journals
•Creation of a website for online advertising
The distribution of products will be
accomplished by means of trucks through
Our company’s site:
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•We are involved in sponsoring hospital
and clinic events during festive and
•We cover doctors’ medical expenses to
attend scientific and medical
•We offer gifts during festive periods
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•Finding suppliers according to their reliability, pricing policy
and their response to the requirements of product and service
•Acquisition of machinery
•Payment of all parties involved (human resources, suppliers,
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•Human Resources of various specialties
•Capital (premises, vechicles)
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•Suppliers of raw materials
•Suppliers of packaging materials
•Company’s human resources
Everybody’s needs must be met for
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•Company’s revenue source is its products’
•Customers can pay via bank cheques and e-
•Nanomedicine S.A. has a stable pricing policy.
•Takes into account the volume of transactions
•Monitors the fluctuations of the raw materials’
market price and creates its price list
accordingly, providing frequent updates to
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•Purchase/rental of facilities
electrical equipment / machinery
To these, we should add the cost of:
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Establishing our company
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The Medical Market in
•The drug is a social good, so the institutional framework
the quality assurance
the prescription policy
the general market conditions
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The Medical Market in
The production and distribution of pharmaceutical products is
one of the most dynamic sectors in Greek industry:
increased investments in the sector
creation of new units of production that manufacture
It is a dynamic industry which makes high profit.
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The establishment of
We created the Spin-Off company named Nanomedicine
S.A. for manufacturing and selling nanomedicines.
It is headquartered in the Industrial Area of Florina.
The company is going to be set in a 300 sq.m. building
that will be rented for this purpose.
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•Issuing of books and documents
•Tax books are confidential and nobody has the right to
take knowledge of them, apart from the tax office
•Decide on the necessary documents, which are:
block collection receipts.
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Internal Audit and
Our company chart includes:
CEO and his deputy
Human Resources Manager
And the following sections:
Internal Audit and Information Technology
Department of quality assurance
Research and Development
Department Public Relations officer
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Financing the Company
•Funded by the Ministry of Development as a spin-off
company upon request
•Check the company's possibilities to be funded by the
Operational Program named: “Competitiveness ,
Entrepreneurship and Innovation”.
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Nanomedicine’s Website and
The website creation is crucial for the company’s
advertising since suppliers and customers can be
informed about our activities. Also, we have created a
blog for improving the internal communication of our
Our company ‘s site:
Our blog: http://www.nanophysicslaimos.blogspot.gr
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“Possessing flexibility, speed and adaptation to the new
requirements we aim to establish ourselves in a leading
pharmaceutical company and offer the community and
the Greek economy!! We incorporate new technologies in
our work and we rely on our people, who are our
strength. Working in Nanomedicine S.A. is aimed to be
considered as an important milestone for the realization
of their professional ambitions! Together we work with
vision, dedication and loyalty to produce quality
medicines for the treatment of diseases!”
Read more in our company ‘s site:
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Bakandritsos, G. Mattheolabakis, G. Chatzikyriakos, T. Szabo, V. Tzitzios, D.
Kouzoudis, S. Couris, and K. Avgoustakis (2011), Doxorubicin Nanocarriers Based
on Magnetic Colloids with a Bio-polyelectrolyte Corona and High Non-linear
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Goldstein J, Newbury D, Joy D, Lyman C, Echlin P, Lifshin E, Sawyer L and Michael
J (2003). Scanning electron microscopy and x-ray microanalysis. Springer.
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Wanquan Jiang, H.C. Yang, S.Y. Yang, H.E. Horng, J.C. Hung, Y.C. Chen, Chin-Yih
Hong (2004), Preparation and properties of superparamagnetic nanoparticles with
narrow size distribution and biocompatible, Journal of Magnetism and Magnetic
Materials, Volume 283, Issues 2–3, Pages 210-214, ISSN 0304-8853
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End of presentation
Thank you for your attention!!!
Read more in our blog: