Carolina Bosch Moreno
Chemical Engineer and Nanotechnologist
NANOPARTICLES FOR
DRUG DELIVERY
Carolina Bosch Moreno
Chemical Engineer and Nanotechnologist
cboschmoreno@gmail.com
Source; www.sacit.com
ProtoLife, Srl a...
SUMMARY
• Nanomedicine. A promising field of nanotechnology
What is nanotechnology?
• What they are
• Nanoparticles types
...
WHAT IS NANOTECHNOLOGY?
“There is Plenty of Room at the Bottom”.
- R. Feynmann
In 1959 R. Feynmann gave a talk
considering...
• Nanomedicine is
the application of
nanotechnology to
medicine. It is at
an early stage but
it is supposed to
develop
con...
Special
Features
Size
• With at least 1 dimension
in the range of 1 to 100
nm. They have novel
properties such as
improved...
NANOPARTICLES TYPES
spherical
vesicles often
designed to
carry
biomolecules.
due to the
existance of
safety and
efficacy d...
NANOPARTICLES TYPES
spherical
vesicles often
designed to
carry
biomolecules.
NANOPARTICLES TYPES
used as
nontargeted
contrast agents
for magnetic
resonance
imaging.
due to the
existance of
safety and...
Drug delivery.
The concept.
Drug delivery makes reference to the
transport of a pharmaceutical substance
in the body to produce a therapeutic
effect.
...
Drugs or diagnostic compounds can be attached
to nanoparticles which allows to administer them
more easily and with greate...
Liposomes
Some types of nanoparticles for drug delivery
Polymeric Nanoparticles
LIPOSOMES
Liposomes are synthetic
nanoparticles composed
primarily of amphiphilic
molecules, typically
phospholipids.
Thes...
Liposome Properties
• their relative ease of
preparation.
• broad selection and
control of their
properties.
• biocompatib...
What are polymeric particles?
They are solid matrixes where the bioactive
molecule can be internally dispersed or adsorbed...
Advantages of polymeric delivery systems for the delivery
of bioactive molecules
PLGA microspheres degradation
CONCLUSIONS
Some of the most interesting applications of
nanotechnology are on the medicine field.
Micro and nanoparticles...
Carolina Bosch Moreno
Chemical Engineer and Nanotechnologist
THANK YOU!
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Nano Particles for Drug Delivery

Sample presentation i made to one of my client at Odesk
Published on: Mar 3, 2016
Published in: Science      
Source: www.slideshare.net


Transcripts - Nano Particles for Drug Delivery

  • 1. Carolina Bosch Moreno Chemical Engineer and Nanotechnologist NANOPARTICLES FOR DRUG DELIVERY
  • 2. Carolina Bosch Moreno Chemical Engineer and Nanotechnologist cboschmoreno@gmail.com Source; www.sacit.com ProtoLife, Srl a chemical- biotechnological company located at Parco Vega, Marghera-Venezia (Italy) ProtoLife develops methods for designing complex chemical systems, such as liposomes
  • 3. SUMMARY • Nanomedicine. A promising field of nanotechnology What is nanotechnology? • What they are • Nanoparticles types Nanoparticles: Drug delivery. The concept • Liposomes • Polymeric nanoparticles Nanoparticles for drug delivery CONCLUSIONS
  • 4. WHAT IS NANOTECHNOLOGY? “There is Plenty of Room at the Bottom”. - R. Feynmann In 1959 R. Feynmann gave a talk considering the manipulation of individual atoms to build-up systems. It is considered the beginning of nanotechnology. Nanotechnology is the science of manipulating matter on an atomic scale. It opens the possibility of creating machines on the scale of molecules such as computers, engines and others
  • 5. • Nanomedicine is the application of nanotechnology to medicine. It is at an early stage but it is supposed to develop constantly. • Nanotechnologies have already transformed genetic and biological analysis through devices that examine molecular biomarkers. This opens the way to a personalized medicine. • Nanomedicine is a promising field of nanotechnology as it is a non invasive tools for diagnostic imaging, tumor detection and drug delivery, because of the unique properties of nanoparticles. • It also presents new opportunities to improve the safety and efficacy of conventional therapeutics. NANOMEDICINE A PROMISING FIELD OF NANOTECHNOLOGY
  • 6. Special Features Size • With at least 1 dimension in the range of 1 to 100 nm. They have novel properties such as improved solubility, increased bioavailability or longer circulation time. Shape • spheres, discs, hemispheres, cylinders, cones, tubes and wires provide interactivity and transport capabilities Permeability Surface Area Nanotechnology is the science of materials and phenomena in the range of 1 to 100 nm in diameter. Though nanomaterials can have unique properties even in sizes up to several hundred nanometers 3 nm thick layer on AlN nanoparticles Silver nanorods •This property is highly increased, enabling nanoparticles to cross physiological barriers to deliver drugs •A large parameter relative to its size, converting the nanoparticles in a more reactive and bioavailable system N A N O P A R TI C L E
  • 7. NANOPARTICLES TYPES spherical vesicles often designed to carry biomolecules. due to the existance of safety and efficacy data they are widely used in nanomedical research. they are semiconductor nanocrystals used in electronics, optics and nanomedical research. 481 508 547 575 Quantum dots
  • 8. NANOPARTICLES TYPES spherical vesicles often designed to carry biomolecules.
  • 9. NANOPARTICLES TYPES used as nontargeted contrast agents for magnetic resonance imaging. due to the existance of safety and efficacy data they are widely used in nanomedical research.
  • 10. Drug delivery. The concept.
  • 11. Drug delivery makes reference to the transport of a pharmaceutical substance in the body to produce a therapeutic effect. Some of the important parameters to consider are the quantity and duration of the drug inside the body. As it is also frequent that the drug is targeted to a specific site of the body, the formulation becomes a critic characteristic to design.
  • 12. Drugs or diagnostic compounds can be attached to nanoparticles which allows to administer them more easily and with greater bioavailability than when given by traditional methods. After the active ingredients have been attached to, or incorporated into, the nanoparticles, the drug is transported to their specific targets. Nanoparticles can also be used to extend the time window of bioavailability (sustained delivery) and protect the drug from chemical or enzymatic decomposition, e.g., in the gastro-intestinal tract. After reaching their target, the drug is released from the nanoparticles by diverse mechanisms.
  • 13. Liposomes Some types of nanoparticles for drug delivery Polymeric Nanoparticles
  • 14. LIPOSOMES Liposomes are synthetic nanoparticles composed primarily of amphiphilic molecules, typically phospholipids. These molecules have a polar head and a long hydrocarbon chain These molecules have a polar head and a long hydrocarbon chain www.ups.edu Image of a spherical liposome marked with a fluorescent dye.
  • 15. Liposome Properties • their relative ease of preparation. • broad selection and control of their properties. • biocompatibility and biodegradability Advantages • mainly related to stability, sterility, reproducibility of preparation and scale- up. Disadvantages They circulate in the bloodstream for an extended time They are similar to human cell membranes They accumulate at the site of a tumor or infection They are similar to human cell membranes
  • 16. What are polymeric particles? They are solid matrixes where the bioactive molecule can be internally dispersed or adsorbed on their surface Size: 1-100 nm nanoparticles 1-100 µm microparticles
  • 17. Advantages of polymeric delivery systems for the delivery of bioactive molecules
  • 18. PLGA microspheres degradation
  • 19. CONCLUSIONS Some of the most interesting applications of nanotechnology are on the medicine field. Micro and nanoparticles are highly useful to deliver drugs in a very specific way with lower toxicity and improved bioavailability. Nanoparticles can be of different types, being some of them polymeric particles and liposomes.
  • 20. Carolina Bosch Moreno Chemical Engineer and Nanotechnologist THANK YOU!

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