Can You Name This Group? <ul><li>Insert photo of Spice Girls here </li></ul><ul><li>http://www.spicegirls.co.uk/gallery.as...
<ul><li>Which Spice Girl is this? </li></ul><ul><li>Posh Spice- Victoria Beckham </li></ul><ul><li>Insert Posh Spice phot...
<ul><li>Why am I showing you slides of Victoria Beckham? </li></ul><ul><li>Believe it or not, she has Polycystic Ovary Sy...
Polycystic Ovary Syndrome Peter Valenzuela, MD, MBA Assistant Dean for Clinical Affairs/Assistant Professor Texas Tech Uni...
Overview <ul><li>Prevalence and Pathogenesis </li></ul><ul><li>Signs and Symptoms </li></ul><ul><li>Diagnosis </li></ul><u...
Background <ul><li>Stein & Leventhal 1935 </li></ul><ul><ul><li>Amenorrhea </li></ul></ul><ul><ul><li>Infertility </li></u...
Prevalence <ul><li>Most common hormonal and reproductive problem affecting women of child-bearing age </li></ul><ul><ul><l...
Pathogenesis <ul><li>UNKNOWN </li></ul><ul><li>High insulin levels </li></ul><ul><li>High androgen levels </li></ul><ul><...
Pathogenesis <ul><li>Genetics </li></ul><ul><ul><li>Insulin-receptor substrate (IRS-1,IRS-2) </li></ul></ul><ul><ul><li>C...
Signs and Symptoms <ul><li>Pre-puberty </li></ul><ul><ul><li>Increased levels of adrenal androgen </li></ul></ul><ul><ul>...
Signs and Symptoms <ul><li>Adolescence and Adulthood </li></ul><ul><ul><li>Anovulation </li></ul></ul><ul><ul><li>Hyperand...
Signs and Symptoms <ul><li>Late Adulthood </li></ul><ul><ul><li>Diabetes </li></ul></ul><ul><ul><li>Hypertension </li></ul...
Clinical Features <ul><li>Acne </li></ul><ul><li>Hirsutism </li></ul><ul><li>Insert Acne image </li></ul><ul><li>http://ww...
Clinical Features <ul><li>Acanthosis nigricans </li></ul><ul><li>Skin tags </li></ul><ul><li>Insert acanthosis nigricans i...
Clinical Features <ul><li>Male-pattern alopecia </li></ul><ul><li>Central obesity </li></ul><ul><li>Insert alopecia image ...
Diagnosis <ul><li>Previous Criteria </li></ul><ul><ul><li>Clinical features </li></ul></ul><ul><ul><li>Laboratory tests </...
Diagnosis <ul><li>Updated Criteria </li></ul><ul><li>Presence of at least two of the following: </li></ul><ul><ul><li>Olig...
Treatment <ul><li>Decrease hyperinsulinism </li></ul><ul><li>Decrease hyperandrogenism </li></ul><ul><li>Induce ovulation...
Complications <ul><li>Endometrial Cancer </li></ul><ul><li>Breast Cancer </li></ul>
Patient Support <ul><li>www.soulcysters . com </li></ul><ul><li>www.pcos.meetup.com </li></ul>
Summary <ul><li>Prevalence and Pathogenesis </li></ul><ul><li>Signs and Symptoms </li></ul><ul><li>Diagnosis </li></ul><ul...
Questions?
References <ul><li>American Journal of Gynecology. 1998. Dec:179 (6 Pt 2): S101 </li></ul><ul><li>Hunter MH. Sterrit JJ. A...
References <ul><li>Hall S. Not Such a Posh Disorder. The Guardian. February 28, 2002 </li></ul><ul><li>Trust for America’s...
References <ul><li>Dunaif A. Hyperandrogenic Anovulation. American Journal of Medicine. 1995; 98:33S-9S </li></ul><ul><li>...
References <ul><li>Vollmert C. et al. American Journal of Physiology-Endocrinology and Metabolism December 11, 2006. </li...
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Polycystic Ovary Syndrome Fmdrl

Published on: Mar 4, 2016
Published in: Health & Medicine      
Source: www.slideshare.net


Transcripts - Polycystic Ovary Syndrome Fmdrl

  • 1. Can You Name This Group? <ul><li>Insert photo of Spice Girls here </li></ul><ul><li>http://www.spicegirls.co.uk/gallery.asp </li></ul>
  • 2. <ul><li>Which Spice Girl is this? </li></ul><ul><li>Posh Spice- Victoria Beckham </li></ul><ul><li>Insert Posh Spice photo here. </li></ul><ul><li>http://www.spicegirls.co.uk/gallery.asp </li></ul>
  • 3. <ul><li>Why am I showing you slides of Victoria Beckham? </li></ul><ul><li>Believe it or not, she has Polycystic Ovary Syndrome </li></ul>
  • 4. Polycystic Ovary Syndrome Peter Valenzuela, MD, MBA Assistant Dean for Clinical Affairs/Assistant Professor Texas Tech University Health Sciences Center at the Permian Basin
  • 5. Overview <ul><li>Prevalence and Pathogenesis </li></ul><ul><li>Signs and Symptoms </li></ul><ul><li>Diagnosis </li></ul><ul><li>Treatment </li></ul>
  • 6. Background <ul><li>Stein & Leventhal 1935 </li></ul><ul><ul><li>Amenorrhea </li></ul></ul><ul><ul><li>Infertility </li></ul></ul><ul><ul><li>Hirsutism </li></ul></ul><ul><ul><li>Enlarged polycystic ovaries </li></ul></ul>
  • 7. Prevalence <ul><li>Most common hormonal and reproductive problem affecting women of child-bearing age </li></ul><ul><ul><li>Present in 5-10% of women </li></ul></ul><ul><li>Commonly under-diagnosed due to use of birth control pills </li></ul>
  • 8. Pathogenesis <ul><li>UNKNOWN </li></ul><ul><li>High insulin levels </li></ul><ul><li>High androgen levels </li></ul><ul><li>High LH </li></ul><ul><li>Low estro/prog </li></ul><ul><li>Insert pathway diagram here. </li></ul><ul><li>http://www.mja.com.au/public/issues/180_03_020204/nor10314_fm-2.gif </li></ul>
  • 9. Pathogenesis <ul><li>Genetics </li></ul><ul><ul><li>Insulin-receptor substrate (IRS-1,IRS-2) </li></ul></ul><ul><ul><li>Calpain-5 </li></ul></ul><ul><ul><li>Calpain-10 </li></ul></ul>
  • 10. Signs and Symptoms <ul><li>Pre-puberty </li></ul><ul><ul><li>Increased levels of adrenal androgen </li></ul></ul><ul><ul><li>Increased insulin levels </li></ul></ul><ul><ul><li>Ovarian Hyperandrogenism </li></ul></ul><ul><li>Leads to precocious puberty </li></ul>
  • 11. Signs and Symptoms <ul><li>Adolescence and Adulthood </li></ul><ul><ul><li>Anovulation </li></ul></ul><ul><ul><li>Hyperandrogenism </li></ul></ul><ul><ul><li>Polycystic ovaries </li></ul></ul><ul><ul><li>Obesity-50% of women </li></ul></ul><ul><li>Leads to reproductive disorders </li></ul>
  • 12. Signs and Symptoms <ul><li>Late Adulthood </li></ul><ul><ul><li>Diabetes </li></ul></ul><ul><ul><li>Hypertension </li></ul></ul><ul><ul><li>Dyslipidemia </li></ul></ul><ul><ul><li>Cardiovascular disease </li></ul></ul><ul><li>Leads to metabolic effects </li></ul>
  • 13. Clinical Features <ul><li>Acne </li></ul><ul><li>Hirsutism </li></ul><ul><li>Insert Acne image </li></ul><ul><li>http://www.skintactix.com/art/Adult-Acne-2BB.JPG </li></ul><ul><li>Insert hirsutism image </li></ul><ul><li>http://www.endotext.org/female/female4/figures/figure4.jpg </li></ul>
  • 14. Clinical Features <ul><li>Acanthosis nigricans </li></ul><ul><li>Skin tags </li></ul><ul><li>Insert acanthosis nigricans image </li></ul><ul><li>http://www.mja.com.au/public/issues/182_03_070205/bat10421_fm-2.jpg </li></ul><ul><li>Insert skin tags image </li></ul><ul><li>http://www.emedicine.com/derm/images/11acanthosis_nigricans_012405.jpg </li></ul>
  • 15. Clinical Features <ul><li>Male-pattern alopecia </li></ul><ul><li>Central obesity </li></ul><ul><li>Insert alopecia image here </li></ul><ul><li>http://www.stophairlossnow.co.uk/images/Hair1.gif </li></ul><ul><li>Insert obesity image here. </li></ul><ul><li>http://www.npheadstart.org/images/P5170219-small.jpg </li></ul>
  • 16. Diagnosis <ul><li>Previous Criteria </li></ul><ul><ul><li>Clinical features </li></ul></ul><ul><ul><li>Laboratory tests </li></ul></ul><ul><ul><li>Ultrasound findings </li></ul></ul><ul><ul><li>Exclusion of other causes </li></ul></ul>
  • 17. Diagnosis <ul><li>Updated Criteria </li></ul><ul><li>Presence of at least two of the following: </li></ul><ul><ul><li>Olig/anovulation </li></ul></ul><ul><ul><li>Hyperandrogenism </li></ul></ul><ul><ul><li>Polycystic ovaries on ultrasound </li></ul></ul><ul><li>And the absence of secondary causes </li></ul>
  • 18. Treatment <ul><li>Decrease hyperinsulinism </li></ul><ul><li>Decrease hyperandrogenism </li></ul><ul><li>Induce ovulation </li></ul><ul><li>Prevent endometrial hyperplasia </li></ul><ul><li>Weight loss </li></ul>
  • 19. Complications <ul><li>Endometrial Cancer </li></ul><ul><li>Breast Cancer </li></ul>
  • 20. Patient Support <ul><li>www.soulcysters . com </li></ul><ul><li>www.pcos.meetup.com </li></ul>
  • 21. Summary <ul><li>Prevalence and Pathogenesis </li></ul><ul><li>Signs and Symptoms </li></ul><ul><li>Diagnosis </li></ul><ul><li>Treatment </li></ul>
  • 22. Questions?
  • 23. References <ul><li>American Journal of Gynecology. 1998. Dec:179 (6 Pt 2): S101 </li></ul><ul><li>Hunter MH. Sterrit JJ. Am Fam Phys 2000, vol. 62, no. 5 </li></ul><ul><li>Norman RJ. Wu R. Stankiewicz MT. Polycystic Ovary Syndrome. MJA 2004; 180 (3): 132-137. </li></ul><ul><li>Marrinan G. Stein M. Polycystic Ovarian Disease (Stein-Leventhal Syndrome. E-Medicine, May 24, 2005. </li></ul>
  • 24. References <ul><li>Hall S. Not Such a Posh Disorder. The Guardian. February 28, 2002 </li></ul><ul><li>Trust for America’s Health. Facts on Fat: How Obesity Policies are Failing America, 2006. </li></ul><ul><li>Knochenhauer ES, Key TJ, Kahsar-Miller M, et al. Prevalence of the Polycystic Ovary Syndrome in Unselected Black and White Women of the Southeastern United States: A Prospective Study. J Clin Endocrinol Metab 1998; 83: 3078-3082. </li></ul>
  • 25. References <ul><li>Dunaif A. Hyperandrogenic Anovulation. American Journal of Medicine. 1995; 98:33S-9S </li></ul><ul><li>PCOD. Journal of Family Practice. 2006. April; 55 (4):351 </li></ul><ul><li>Wild RA. Hyperandrogenism: Implications for Cardiovascular Endometrial and Breast Disease. </li></ul><ul><li>Adashi EY, Rock JA, Rosenwaks Z, eds. Reproductive endocrinology, surgery, and technology. Philadelphia: Lippincott-Raven, 1996:1617.) </li></ul>
  • 26. References <ul><li>Vollmert C. et al. American Journal of Physiology-Endocrinology and Metabolism December 11, 2006. </li></ul><ul><li>Gonzalez A. Human Reproduction. January 5, 2006 </li></ul><ul><li>(Fertil Steril 2002 Dec;78(6):1240 in J Watch Online 2003 Jan 14) </li></ul><ul><li>Fertil Steril 2004 Jan;81(1):19 in J Fam Pract 2006 Apr;55(4):351 </li></ul><ul><li>Dynamed website </li></ul>

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