RIJU CHANDRAN.R
INTRODUCTION TO
NANOTOXICOLOGY
Small is beautiful……
DANGERS COME IN SMALL PARTICLES
Nanotoxicology is a branch of Bionanoscience
which deals with the study and application of
toxicity of nanomaterials.
Nano...
 The size of a particle decreases,its surface area
increases and also allows a greater properties of
its atoms or molecul...
The toxicity of nanomaterials were broadly
classified into two :-
 BIOLOGICAL TOXICITY
 ENVIRONMENTAL TOXICITY
 Biological Toxicity:
 Nanostructures can enter the body via six
principle routes :- Intravenous, Dermal,
Subcutaneous, ...
 The toxic effects are :-
 Allergy
 Fibrosis
 Deposition in different organs(lead to organ
failure)
 Inflammation
 C...
 Environmental Toxicity
 During the outburst of nanomaterial research
there pumps lot of nanoparticles to the
environmen...
 NANOMATERIAL EXPOSURE :-
 Occupational Exposure –
Person involved in nanomaterial manufacturing
and research, with the ...
 Environmental Exposure –
The engineered nanomaterial applications
develop as projected, the increasing
concentrations of...
 REASONS FOR TOXICITY :-
 Surface area to volume ratio of the particles which
increases their interaction with the surro...
 Accumulation of an inert particle in the body
could also trigger tissue formation around the
foreign entity and thus lea...
Nanotoxicology
Nanotoxicology
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Nanotoxicology

INTRODUCTION TO NANOTOXICOLOGY
Published on: Mar 3, 2016
Published in: Education      
Source: www.slideshare.net


Transcripts - Nanotoxicology

  • 1. RIJU CHANDRAN.R INTRODUCTION TO NANOTOXICOLOGY
  • 2. Small is beautiful…… DANGERS COME IN SMALL PARTICLES
  • 3. Nanotoxicology is a branch of Bionanoscience which deals with the study and application of toxicity of nanomaterials. Nanotoxicological studies are intended to determine at what extent their properties may pose a threat to the environment and to the human beings.
  • 4.  The size of a particle decreases,its surface area increases and also allows a greater properties of its atoms or molecules to be displayed on the surface rather than the interior of the material.  The change in the physico-chemical and structural properties of engineered nanomaterials with a decrease in size would be responsible for a number of material interactions that could lead to toxicological effects.
  • 5. The toxicity of nanomaterials were broadly classified into two :-  BIOLOGICAL TOXICITY  ENVIRONMENTAL TOXICITY
  • 6.  Biological Toxicity:  Nanostructures can enter the body via six principle routes :- Intravenous, Dermal, Subcutaneous, Inhalation, Intraperitoneal & Oral  The entered nanostructure can distribute to various organs in the body and may remain the same structurally,be modified, or metabolized.  They enter the cells of the organ and residue in the cells for an unknown amount of time before leaving to move to other organs or to be excreted.
  • 7.  The toxic effects are :-  Allergy  Fibrosis  Deposition in different organs(lead to organ failure)  Inflammation  Cytotoxicity  Tissue damage  ROS generation  DNA damage
  • 8.  Environmental Toxicity  During the outburst of nanomaterial research there pumps lot of nanoparticles to the environment.  Nanoparticle pollution, by deposition of nanoparticle in groundwater & soil.  Process that control transport & removal of nanoparticles in water and waste water are yet to be investigated.  Studies on the effect of nanoparticles on plants and microbes are also rare.
  • 9.  NANOMATERIAL EXPOSURE :-  Occupational Exposure – Person involved in nanomaterial manufacturing and research, with the increasing demand of nanomaterials in market the exposure of workers making these materials and using nanoparticles in the manufacturing plant is also increasing  Consumer Exposure – Engineered nanoparticles are used in personal care products, ranging from cosmetics to sunscreens, where decreasing the size active ingredients yields & better performance.
  • 10.  Environmental Exposure – The engineered nanomaterial applications develop as projected, the increasing concentrations of nanomaterials in groundwater and soil may present the most significant exposure avenues for assessing environmental risk.
  • 11.  REASONS FOR TOXICITY :-  Surface area to volume ratio of the particles which increases their interaction with the surrounding molecules.  Chemical composition of the particle which is responsible for its reactivity.  Surface charge of the particle is responsible for electrostatic interactions.  Complementarity of nanostructure could cause inhibition of enzyme activity either competitive or non competitive.
  • 12.  Accumulation of an inert particle in the body could also trigger tissue formation around the foreign entity and thus leading to formation of a scar tissue.