<ul><li>Preventive Cardiology: Focus on trans fats </li></ul>
Source: CDC/NCHS Courtesy of Barry Franklin, PhD, William Beaumont Hospital, Royal Oak, MI
NHANES C-Reactive Protein and Cholesterol Levels Highly Predictive of CHD Risk: Role for Inflammation? Ridker PM. Circu...
Conventional Risk Factors for Coronary Heart Disease * JAMA 2003;290:891 ** JAMA 2003;290:898 Courtesy of Barry Franklin,...
Approximate Mortality Reduction Potential of Drug Vs Lifestyle Interventions in Patients with Coronary Disease* Drug Lifes...
The effects of lifestyle change and drug therapy on cardiovascular risk reduction appear to be independent and additive ....
Courtesy of Barry Franklin, PhD, William Beaumont Hospital, Royal Oak, MI <ul><li>SIT </li></ul><ul><li>SPARINGLY </li></...
Cardioprotective Dietary Recommendations* <ul><li>Minimize the intake of beverages & foods with added sugars </li></ul><ul...
Cardioprotective Dietary Recommendations* <ul><li>Balance caloric intake & physical activity to achieve and maintain a hea...
Trans fatty acids can adversely affect: LDL and HDL cholesterol levels LP(a) and triglycerides Vascular inflammation IL-6,...
Trans Fat Increases Risk of Coronary Disease Courtesy of Barry Franklin, PhD, William Beaumont Hospital, Royal Oak, MI
Trans Fat Intake & Systemic Inflammation (Lopez-Garcia et al. J Nutr 2005) Quintiles of Trans Fatty Acid Intake Among 7...
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Preventive Cardiology: Focus on trans fats

Published on: Mar 4, 2016
Source: www.slideshare.net


Transcripts - Preventive Cardiology: Focus on trans fats

  • 1. <ul><li>Preventive Cardiology: Focus on trans fats </li></ul>
  • 2. Source: CDC/NCHS Courtesy of Barry Franklin, PhD, William Beaumont Hospital, Royal Oak, MI
  • 3. NHANES C-Reactive Protein and Cholesterol Levels Highly Predictive of CHD Risk: Role for Inflammation? Ridker PM. Circulation. 2001;103:1813-1818. hs-CRP = high-sensitivity CRP Courtesy of Barry Franklin, PhD, William Beaumont Hospital, Royal Oak, MI Quintile of TC:HDL-C 5 4 3 2 1 5 4 3 2 1 Quintile of hs-CRP Men Relative Risk Women Quintile of TC:HDL-C 5 4 3 2 1 Quintile of hs-CRP 5 4 3 2 1
  • 4. Conventional Risk Factors for Coronary Heart Disease * JAMA 2003;290:891 ** JAMA 2003;290:898 Courtesy of Barry Franklin, PhD, William Beaumont Hospital, Royal Oak, MI 4 Risk Factors Cigarette Smoking Hyper- lipidemia Hyper- tension Diabetes <ul><li>87% to 100% of patients who experienced a fatal coronary event had an antecedent exposure to  1 risk factor. * </li></ul><ul><li>> 80% of patients with coronary disease had  1 of the 4 conventional risk factors. ** </li></ul>
  • 5. Approximate Mortality Reduction Potential of Drug Vs Lifestyle Interventions in Patients with Coronary Disease* Drug Lifestyle Low dose aspirin 18% Statins 21% ß Blockers 23% ACE Inhibitors 26% Smoking cessation 35% Physical activity 25% Moderate alcohol 20% Combined lifestyle changes 45% Iestra JA et al. Circ 2005;112:924 Courtesy of Barry Franklin, PhD, William Beaumont Hospital, Royal Oak, MI
  • 6. The effects of lifestyle change and drug therapy on cardiovascular risk reduction appear to be independent and additive . + Hunninghake DB et al. NEJM 1993;32:1213 Barnard RJ et al. AJC 1997;79:1112 Sdringola S et al. JACC 2003;41:263 Courtesy of Barry Franklin, PhD, William Beaumont Hospital, Royal Oak, MI
  • 7. Courtesy of Barry Franklin, PhD, William Beaumont Hospital, Royal Oak, MI <ul><li>SIT </li></ul><ul><li>SPARINGLY </li></ul><ul><li>watch TV </li></ul><ul><li>play computer games </li></ul><ul><li>ENJOY LEISURE </li></ul><ul><li>ACTIVITIES </li></ul><ul><li>golf </li></ul><ul><li>bowling </li></ul><ul><li>yardwork </li></ul><ul><li>STRETCH/ </li></ul><ul><li>STRENGTHEN </li></ul><ul><li>curl-ups </li></ul><ul><li>push-ups </li></ul><ul><li>weight lifting </li></ul>2-3 Times/Wk <ul><li>AEROBIC ACTIVITIES </li></ul><ul><li>long walks </li></ul><ul><li>biking </li></ul><ul><li>swimming </li></ul>3-5 Times/Wk <ul><li>RECREATIONAL SPORTS </li></ul><ul><li>tennis </li></ul><ul><li>racquetball </li></ul><ul><li>basketball </li></ul><ul><li>make extra steps in your day </li></ul><ul><li>walk the dog </li></ul><ul><li>take the stairs instead of the elevator </li></ul><ul><li>park your car farther away and walk </li></ul>EVERYDAY The Activity Pyramid Pedometers
  • 8. Cardioprotective Dietary Recommendations* <ul><li>Minimize the intake of beverages & foods with added sugars </li></ul><ul><li>Choose and prepare foods with little or no salt </li></ul><ul><li>Limit alcohol consumption (≤ 2 and 1 drink/day for men and women, respectively), ideally with meals </li></ul>*Lichtenstein A et al. Circ 2006;114:82 Courtesy of Barry Franklin, PhD, William Beaumont Hospital, Royal Oak, MI
  • 9. Cardioprotective Dietary Recommendations* <ul><li>Balance caloric intake & physical activity to achieve and maintain a healthy body weight </li></ul><ul><li>Consume a diet rich in fruits and vegetables, as well as whole-grain, high-fiber foods </li></ul><ul><li>Eat fish, especially oily fish, ≥ 2 times/week </li></ul><ul><li>Limit </li></ul><ul><ul><li>saturated fat (<7% of energy) </li></ul></ul><ul><ul><li>cholesterol to (< 300 mg/day), and </li></ul></ul><ul><ul><li>trans fat (< 1% of energy) </li></ul></ul>Courtesy of Barry Franklin, PhD, William Beaumont Hospital, Royal Oak, MI
  • 10. Trans fatty acids can adversely affect: LDL and HDL cholesterol levels LP(a) and triglycerides Vascular inflammation IL-6, TNF, CRP Trans fatty acids increase: Coronary heart disease Diabetes Mozaffarian D. NEJM 2006 Courtesy of Barry Franklin, PhD, William Beaumont Hospital, Royal Oak, MI
  • 11. Trans Fat Increases Risk of Coronary Disease Courtesy of Barry Franklin, PhD, William Beaumont Hospital, Royal Oak, MI
  • 12. Trans Fat Intake & Systemic Inflammation (Lopez-Garcia et al. J Nutr 2005) Quintiles of Trans Fatty Acid Intake Among 730 women, adjusted for age, BMI, smoking, physical activity, postmenopausal hormone therapy, and intakes of alcohol, saturated fat, polyunsaturated fat, and monounsaturated fat. p trend 0.10 p trend 0.009 Courtesy of Barry Franklin, PhD, William Beaumont Hospital, Royal Oak, MI

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