Nanoparticle Drug Delivery
Group members:
• Adrian A. Pinto
• Tejas Pitale
• Hooman Mirali
• Benjamin A Corbett-Jones...
Nanoparticle Drug Delivery – Methods of drug
delivery
Nanoparticle Drug Delivery – Nanoparticles
 25,000 publication with the keyword nanoparticle in drug
delivery
 Spheri...
Nanoparticle Drug Delivery – Nanotubes
Carbon nanotubes, cyclic peptide nanotubes and template-synthesized nanotubes
C...
Nanoparticle Drug Delivery – Nanocapsules
 Carrying, targeting and controlling the release of drugs.
 Made of a core w...
Nanoparticle Drug Delivery – Nanocrystalline drugs
 40% of drugs have low solubility[1].
 Nanocrystal drugs- increase ...
Nanoparticle Drug Delivery – Nanogels
 Nano-scale hydrogels
• Straightforward synthesis; can be synthesized without the...
Nanomaterial Drug Delivery – Dendrimers
 Similar to snow crystals
and lightning
 Strong structural control
 Biocomp...
Nanomaterial Drug Delivery - Liposomes
 Artificial vesicles developed from amphiphilic phospholipids
 Treatment of var...
Nanoparticle Drug Delivery – Polymeric Micelles
Hydrophilic
shell
Hydrophobic
Core
Drug Payload
 Artificial cell li...
Nanoparticle Drug Delivery – Nucleic Acid
 macromolecules made from monomers known as nucleotides
 building material t...
Nanoparticle Drug Delivery – Polymeric drug
conjugates
 Type of targeted Nano drug delivery system
 Drug is connected...
Nanoparticle Drug Delivery – Advantages
Advantages of Polymeric Drug Conjugates
• Improved therapeutic properties of pep...
Nanoparticle Drug Delivery – Solid Lipid Nano
Particles
 Sub micron colloidal particles (50-1000 nm)
 Physiological l...
Nanoparticle Drug Delivery – Methods Of
Preparation
Nanoparticle Drug Delivery – factors impacting
drug delivery
 Particle Size
 Surface
characteristics
• minute size ...
Nanoparticle Drug Delivery – Targeting strategies
 Passive targeting
 Active targeting
• Drug accumulation in tumor t...
Nanoparticle Drug Delivery – Challenges
 Biological
understanding
 Safety concern
• shortage of knowledge
• low tar...
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Nanomaterial drug delivery updated 20202

Its my recent presentation related to Nanoparticles drug delivery Systems. It is a part of thorough literature review.
Published on: Mar 3, 2016
Published in: Health & Medicine      
Source: www.slideshare.net


Transcripts - Nanomaterial drug delivery updated 20202

  • 1. Nanoparticle Drug Delivery Group members: • Adrian A. Pinto • Tejas Pitale • Hooman Mirali • Benjamin A Corbett-Jones • Faizan Arif
  • 2. Nanoparticle Drug Delivery – Methods of drug delivery
  • 3. Nanoparticle Drug Delivery – Nanoparticles  25,000 publication with the keyword nanoparticle in drug delivery  Spherical Nanoparticles are the simplest drug carriers Benefits: Small size Sequestration - lower and slower Good transportation Lower cytotoxicity
  • 4. Nanoparticle Drug Delivery – Nanotubes Carbon nanotubes, cyclic peptide nanotubes and template-synthesized nanotubes Can be manufactured by cylindrical pores of a solid surface Properties: Act like a nanoneedle Multiple drugs can be loaded unto them simultaneously; other functions can be added High purity Biocompatible Insoluble Chance to be opsonized can be altered by changing their size and active agents on their outer surface
  • 5. Nanoparticle Drug Delivery – Nanocapsules  Carrying, targeting and controlling the release of drugs.  Made of a core with a shell Core: Solid, liquid or gas; base- aqueous solution or oil Shell: Encapsulates the core  Eg: Biodegradable polymeric nanocapsules and Vault  Sensitive to PH and temperature  Synthesis: putting them in an aqueous environment and the amphiphilic copolymers will rearrange themselves into core shell structure  Can be used in diabetic patients for intragastric administration of insulin
  • 6. Nanoparticle Drug Delivery – Nanocrystalline drugs  40% of drugs have low solubility[1].  Nanocrystal drugs- increase solubility and dissolution rate.  These can be used in common dosage forms like tablets, inhalation devices, capsules and injections[2]. [1] Keck C M and Müller R H, Drug nanocrystals of poorly soluble drugs produced by high pressure homogenisation (2006) [2] Rosen H and Abribat T , The rise and rise of drug delivery(2005)
  • 7. Nanoparticle Drug Delivery – Nanogels  Nano-scale hydrogels • Straightforward synthesis; can be synthesized without the presence of the drug • High drug-loading capacity • Prevent payload aggregation.  Hydrophilic and swell in the presence of water  Respond to • Ionic strength, • pH • Temperature
  • 8. Nanomaterial Drug Delivery – Dendrimers  Similar to snow crystals and lightning  Strong structural control  Biocompatible  Water soluble  Improve drug properties  Prolonged plasma circulation time  Helps in Boron Neutron Capture therapy Source: [3] Starpharma, How are Dendrimers made [3] Starpharma, How are Dendrimers made, http://www.starpharma.com/technology/how_are_dendrimers_made_
  • 9. Nanomaterial Drug Delivery - Liposomes  Artificial vesicles developed from amphiphilic phospholipids  Treatment of various illnesses Table 1. Different uses of Liposomes in treatment of illnesses Brand Drug Treatment of AmBisome Amphotercin B Fungal Infections Doxil, Caelx Doxorubicin Ovarian cancer, Kaposi’s sarcoma and breast cancer Depocyt Cytarabine Lymphomatous meningitis Daunoxome Daunorubicine Kaposi’s sarcoma
  • 10. Nanoparticle Drug Delivery – Polymeric Micelles Hydrophilic shell Hydrophobic Core Drug Payload  Artificial cell like structures similar to natural carriers  Core/shell structure with hydrophobic core and hydrophilic shell  Suitable use for drugs that have poor aqueous solubility  Generally made up of block copolymers  well suited in treating cancer
  • 11. Nanoparticle Drug Delivery – Nucleic Acid  macromolecules made from monomers known as nucleotides  building material to create nanostructures  Two methods have been devised to create rigid structures DNA origami Nanocages (tensegrity principle)) DNA box with a lid that is controlled by the environment for use in drug delivery
  • 12. Nanoparticle Drug Delivery – Polymeric drug conjugates  Type of targeted Nano drug delivery system  Drug is connected to a bio degradable polymer with conjugate covalent bonds. Fig. 1 Schematic presentation for (a) polymeric prodrug with targeting agent and (b) hyperbranched polymer conjugate with targeting and imaging agent. Jayant Khandare , Tamara Minko; Progress in Polymer Science Polymer–drug conjugates: Progress in polymeric prodrugs;, Volume 31, Issue 4, 2006, 359 - 397
  • 13. Nanoparticle Drug Delivery – Advantages Advantages of Polymeric Drug Conjugates • Improved therapeutic properties of peptides and proteins. • Prolonged half life in plasma. • Higher stability during transit. • High water solubility due to bio degradable polymers • Accurate tumor targeting. • Easy administration of drug
  • 14. Nanoparticle Drug Delivery – Solid Lipid Nano Particles  Sub micron colloidal particles (50-1000 nm)  Physiological lipids dispersed in aqueous solution with surfactants  Colloidal particles are made of core which is coated with a mono layer of phospholipid coating
  • 15. Nanoparticle Drug Delivery – Methods Of Preparation
  • 16. Nanoparticle Drug Delivery – factors impacting drug delivery  Particle Size  Surface characteristics • minute size • comparative mobility * • available to a large number of biological targets • Higher intracellular uptake • Nanoparticles are attacked by phagocytes • Surface hydrophobicity * Ref: Panyam J, Labhasetwar V. Biodegradable nanoparticles for drug and gene delivery to cells and tissue. Adv Drug Deliv Rev 2003; 55: 329-47
  • 17. Nanoparticle Drug Delivery – Targeting strategies  Passive targeting  Active targeting • Drug accumulation in tumor tissues • Gap junctions between lymphatic drainage and endothelial cells • Dilation of tumor vessels leading to diffusion of molecules • Higher intracellular uptake • attachment of affinity ligands with nano-carrier surfaces • Ligand – receptor interactions • Binding of target cells by nano-carriers * Ref: Panyam J, Labhasetwar V. Biodegradable nanoparticles for drug and gene delivery to cells and tissue. Adv Drug Deliv Rev 2003; 55: 329-47
  • 18. Nanoparticle Drug Delivery – Challenges  Biological understanding  Safety concern • shortage of knowledge • low targeting efficiency • Rapid clearance by the immune system  Manufacturing • adverse effects • nano-materials and biological system interactions • Pilot techniques • Economic and financial barriers * Ref: Panyam J, Labhasetwar V. Biodegradable nanoparticles for drug and gene delivery to cells and tissue. Adv Drug Deliv Rev 2003; 55: 329-47

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