1st Pan-Asia Conference on Haemoglobinopathies Prevention and control of thalassaemia in Southern China Guangxi...
Thalassemias are the most common inherited blood disorder in Southern China
Guangxi Zhuang Autonomous Region & G i Zh A t R i Guangdong province Guangxi Pr...
The Ca e rate for t a asse a e Carrier ate o thalassemia Carrier rate for Carrier rate for Carri...
Estimated number of patients st ated u be o pat e ts province Annual births Hydrop foetalis -thalassemia maj...
Prevention and control program of p g Thalassemia in Southern China (Since 1983)• 1960s...
Support fS t from th Ministry of Health of China & the Mi i t f H lth f Chi Government of Guangxi Pr...
Prevention and control program for thalassemia in Guangxi province (2010)• Enhancing health education• ...
Prevention and control program for thalassemia in Guangdong province (2010)• “Maternal and Children s Safety and ...
Techniques available• Blood count: in all clinics and hospitals.• Electrophoresis: hospitals in counties and cities.• Au...
HPLC External quality assessment programs
Population Screen for Thalassemia• Screening for carriers Clinics / Hospital outpatients Population• Walk in for...
Specific target groups:• Premarital couples• pregnant women and husbands p g• Adolescents and young adults• neonates
Prenatal diagnosis in Guangxi Province (since 1983)• Obtain fetal DNA: Chorionic villus sampling ...
Prenatal diagnosis centers in Guangxi Province 1 in Liuzhou 2  in Guilin 1 in Baise 1 in Baise ...
Prenatal diagnosis centers in Guangdong Province Guangzhou Shenzhe...
Treatment for patients• Iron Chelation: Desferrioxamine Deferiprone Exjade• Steam cell transplantation• Medica...
Thalassemia Home
Regular professional education and training R l f i l d ti dt i i• Obstetricians, pediatricians, hemato...
The 3rd International Conference on Thalassemia in China & The 2nd Asia Pacific Iron A d 2 d A i P ifi I ...
Overall Meeting Evaluation O ll M ti E l ti50454035302520 # of participants151...
Overall Meeting EvaluationO ll M ti E l ti
Overall Meeting EvaluationO ll M ti E l ti
Overall Meeting EvaluationO ll M ti E l ti
TIF workshop for Thalassemia in China, Nov. 7, Nov 7 2010
Reference Expert Center: The First Affiliated Hospital, Guangxi Medical University
Team: 26 staffs O t ti t department Out-patient d t tW d WardL b Laboratory t
Management for thalassemiaClinicalCli i l work: k• Genetic counseling• Hb Analysis• DNA analysis• Prenatal diag...
The Th l Th Thalassemia Research Center i R hC t• The National Key Clinical Specialty for ...
Thanks
Southern China - Current Situation in Control Strategies and Health Systems in Asia
Southern China - Current Situation in Control Strategies and Health Systems in Asia
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Southern China - Current Situation in Control Strategies and Health Systems in Asia

Prevention and Control of Thalassaemia in Southern China, Guangxi Province by Ping Chen of Guangxi Medical University
Published on: Mar 4, 2016
Published in: Health & Medicine      Technology      Business      
Source: www.slideshare.net


Transcripts - Southern China - Current Situation in Control Strategies and Health Systems in Asia

  • 1. 1st Pan-Asia Conference on Haemoglobinopathies Prevention and control of thalassaemia in Southern China Guangxi Province Ping Chen Guangxi Medical University g y
  • 2. Thalassemias are the most common inherited blood disorder in Southern China
  • 3. Guangxi Zhuang Autonomous Region & G i Zh A t R i Guangdong province Guangxi Province Guangdong Province Population 50 million 80 million Area 240,100 179,800 Ethnic group 37 53 Han: 61.46% 98.6%Minority groups: 38.54% 1.4% Annual births 720, 000 1 million
  • 4. The Ca e rate for t a asse a e Carrier ate o thalassemia Carrier rate for Carrier rate for Carrier rate for province -thalassemia(%) -thalassemia(%) Hb E(%) Guangxi 14.95 5.65 0.009Guangdong 8.53 2.54 NA 16 14 12 10 Guangxi 8 Guangdong G d Hongkong 6 Taiwan 4 2 0 alpha-thalassemia beta-halassemia
  • 5. Estimated number of patients st ated u be o pat e ts province Annual births Hydrop foetalis -thalassemia major Guangxi 720,000/yr 720 000/yr 4050/yr 574/yrGuangdong 1,000,000/yr 7276/yr 645/yr
  • 6. Prevention and control program of p g Thalassemia in Southern China (Since 1983)• 1960s: thalassemia research began.• 1983 -thalassemia genotyping and prenatal diagnosis were 1983: th l i t i d t l di i established and have been performed.• 1987: Prenatal diagnosis for -thalassemia started.• 1998: iron chelation and stem cell transplantation for patients p p with -thalassemia major.• 2004: separate fetal DNA in maternal plasma for - and  -thalassemia prenatal diagnosis.• 2007: Preimplantation genetic diagnosis for thalassemia. thalassemia
  • 7. Support fS t from th Ministry of Health of China & the Mi i t f H lth f Chi Government of Guangxi Province The Ministry of Health of China and Guangxi government signed agreement for prevention and control of thalassemia tf ti d t l f th l i March 11, 2010
  • 8. Prevention and control program for thalassemia in Guangxi province (2010)• Enhancing health education• Setting up more centers for screening and diagnosis of thalassemia• Training medical doctors, nurses, technicians and health workers• Provision of free screening to premarital couples• Free prenatal diagnosis
  • 9. Prevention and control program for thalassemia in Guangdong province (2010)• “Maternal and Children s Safety and Health Project Maternal Children’s Project” including screening and prenatal diagnosis to reduce the birth rate of thalassemia major. j• Only a few cities provide free screening for thalassemia carriers.
  • 10. Techniques available• Blood count: in all clinics and hospitals.• Electrophoresis: hospitals in counties and cities.• Automatic HPLC systems or Capillarys: y p y hospitals in counties and cities.• DNA analysis: some hospitals in cities.
  • 11. HPLC External quality assessment programs
  • 12. Population Screen for Thalassemia• Screening for carriers Clinics / Hospital outpatients Population• Walk in for voluntary screening• Specific target groups
  • 13. Specific target groups:• Premarital couples• pregnant women and husbands p g• Adolescents and young adults• neonates
  • 14. Prenatal diagnosis in Guangxi Province (since 1983)• Obtain fetal DNA: Chorionic villus sampling Amninocentesis Foetal blood sampling• DNA analysis: Gap PCR, RDB, DNA sequencing.
  • 15. Prenatal diagnosis centers in Guangxi Province 1 in Liuzhou 2  in Guilin 1 in Baise 1 in Baise 1 in 3 in Nanning Wuzhou 1 in  Yulin
  • 16. Prenatal diagnosis centers in Guangdong Province Guangzhou Shenzhen Zhuhai
  • 17. Treatment for patients• Iron Chelation: Desferrioxamine Deferiprone Exjade• Steam cell transplantation• Medical insurance cover blood transfusion and iron chelation, and some expense for transplantation.
  • 18. Thalassemia Home
  • 19. Regular professional education and training R l f i l d ti dt i i• Obstetricians, pediatricians, hematologists, nurses and technicians must receive education and training, and obtain the qualification for the management of thalassemia. thalassemia• Course workshops seminars and conferences. Course, workshops, conferences• organized by the Department of Health of Guangxi government, Guangxi Medical University etc.
  • 20. The 3rd International Conference on Thalassemia in China & The 2nd Asia Pacific Iron A d 2 d A i P ifi I Academy C f Conference, 2010 Organizer: 1. 1 Guangxi Medical University 2. Institute of Molecular Biosciences, Mahidol University 3. 3 Asia Pacific Iron Academy
  • 21. Overall Meeting Evaluation O ll M ti E l ti50454035302520 # of participants151050 • Total individuals: 253 • China 55 vs. overseas 198
  • 22. Overall Meeting EvaluationO ll M ti E l ti
  • 23. Overall Meeting EvaluationO ll M ti E l ti
  • 24. Overall Meeting EvaluationO ll M ti E l ti
  • 25. TIF workshop for Thalassemia in China, Nov. 7, Nov 7 2010
  • 26. Reference Expert Center: The First Affiliated Hospital, Guangxi Medical University
  • 27. Team: 26 staffs O t ti t department Out-patient d t tW d WardL b Laboratory t
  • 28. Management for thalassemiaClinicalCli i l work: k• Genetic counseling• Hb Analysis• DNA analysis• Prenatal diagnosis:• Patients treatmnetTraining:• seminars• workshops g• 3 months training
  • 29. The Th l Th Thalassemia Research Center i R hC t• The National Key Clinical Specialty for Thalassemia, approved by the Ministry of Health of China.• The Key laboratory in Thalassemia Research• Guangxi Prenatal diagnosis Center for Thalassmia• The Training Center for medical professionals
  • 30. Thanks

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